My findings

Tuning by the seat of the pants will not be that accurate as an air fuel meter, and I can assure you the 290/green cam is the most aggressive initial shot of fuel. I think the Holley tuning book recommends going with the smallest pump shot/duration to overcome any hesitation(give it just enough fuel, not too much).

If you placed all the cams next to each other and look at the lobes, you might think wow that one cam has a huge lobe, but you have to take into account they are referenced to the screw hole, which places the pump arm at different points on the lobe, which means different shot durations as well as different initial shot (degrees of throttle opening), so size/shape means nothing when looking at them. Follow the chart as your tuning guide.

You said the orange is too aggressive? Is it the 466? The orange is too aggressive i think because you have to almost tighten down the bolt to get the preload off of it That really doesnt matter where the adjustment ends up (again size means nothing). Also you can slightly bend the arm if you run out of adjustment. Adjust the arm after every cam change, just to be sure. The orange is the second smallest cam in the bunch (degrees of throttle opening).

If your squirter is too small to take advantage of a large initial shot (290/green) then it will delay that discharge and act like it has a longer duration cam installed.

I would start out lean (orange) and richen as needed, just because gas is expensive, and if this is your daily driver, if not then give it the fuel lol.

I would tune for where you want the car to run best, from there I would fine tune all other driving situations.