I think that this is a very significant finding. It is from the NIH website. Near the end of the website it lists symptoms and they are the physical symptoms that parallel "autism characteristics". Thimerosol is listed as one of the Synonyms. The Link is
http://157.98.10.135/NTP_Reports/NTP_Chem_HS_HTML/NTP_Chem5/Radian54-64-8.html
Someone at the Autism-Mercury Board dug this up. They suggest you send it to your attorney. (Or get one Waters and Kraus) Then copy it before it mysteriously disappears from their official site.
Shirley
NTP CHEMICAL REPOSITORY
MERCURY((O-CARBOXYPHENYL)THIO)ETHYL, SODIUM SALT
-IDENTIFIERS
===========
*CATALOG ID NUMBER: 001097
*CAS NUMBER: 54-64-8
*BASE CHEMICAL NAME: MERCURYCARBOXYPHENYLTHIOETHYL,SODIUMSALT,O-
*PRIMARY NAME: MERCURY((O-CARBOXYPHENYL)THIO)ETHYL, SODIUM SALT
*CHEMICAL FORMULA: C9H9HgO2S.Na
*STRUCTURAL FORMULA: Not printable
*WLN: QVR BS-HG-2 &-NA-
*SYNONYMS:
((O-CARBOXYPHENYL)THIO)ETHYLMERCURY SODIUM SALT
ELICIDE
O-(ETHYLMERCURITHIO)BENZOIC ACID SODIUM SALT
ETHYLMERCURITHIOSALICYLIC ACID SODIUM SALT
ETHYLMERCURITHIOSALICYLATE SODIUM SALT
MERCUROTHIOLATE
MERZONIN SODIUM
SET
SODIUM ETHYLMERCURIC THIOSALICYLATE
SODIUM MERTHIOLATE
THIMEROSAL
THIMEROSALATE
THIMEROSOL
THIMERSALATE
THIOMEROSAL
THIOMERSAL
THIOMERSALATE
MERCURATE(1-), ETHYL(2-MERCAPTOBENZOATO(2-)-O,S)-, SODIUM
MERFAMIN
MERTHIOLATE
MERTHIOLATE SODIUM
MERTORGAN
SODIUM O-(ETHYLMERCURITHIO)BENZOATE
MERCURY, ETHYL(HYDROGEN O-MERCAPTOBENZOATO)-, SODIUM SALT
ETHYL(HYDROGEN O-MERCAPTOBENZOATO)MERCURY, SODIUM SALT
MERZONIN
NOSEMACK
SODIUM 2-(ETHYLMERCURITHIO)BENZOATE
MERSEPTYL
THIOMERSALAT
BENZOIC ACID, 2-MERCAPTO-, MERCURY COMPLEX
ELCIDE 75
ETHYL(2-MERCAPTOBENZOATO-S)MERCURY SODIUM SALT
ETHYL (SODIUM O-MERCAPTOBENZOATO)MERCURY
MERCURY, ETHYL(2-MERCAPTOBENZOATE-S), SODIUM SALT
MERTHIOLATE SALT
MERZONIN, SODIUM SALT
SODIUM ETHYLMERCURITHIOSALICYLATE
ETHYL(2-MERCAPTOBENZOATO(2-)-O,S)-MERCURATE(1-) SODIUM
-PHYSICAL CHEMICAL DATA
======================
*PHYSICAL DESCRIPTION: LITERATURE: Light cream-colored crystalline powder
REPOSITORY: White powder
*MOLECULAR WEIGHT: 404.82
*SPECIFIC GRAVITY: Not available
*DENSITY: Not available
*MP (DEG C): 232-233 C (decomposes) [269,275]
*BP (DEG C): Not available
*SOLUBILITIES:
WATER : >=100 mg/mL @ 19 C (RAD)
DMSO : >=100 mg/mL @ 19 C (RAD)
95% ETHANOL : 10-50 mg/mL @ 19 C (RAD)
METHANOL : Soluble [295]
ACETONE : <1 mg/mL @ 19 C (RAD)
TOLUENE : Not available
OTHER SOLVENTS:
Ether: Practically insoluble [033,062,233,295]
Benzene: Practically insoluble [033,062]
Alcohol: 1 g/8 mL [033,295]
*VOLATILITY:
Vapor pressure: Not available
Vapor density: Not available
*FLAMMABILITY(FLASH POINT):
Flash point data for this chemical are not available; however, it is
probably combustible. Fires involving this material can be controlled with
a dry chemical, carbon dioxide or Halon extinguisher. A water spray may
also be used [269].
*UEL: Not available LEL: Not available
*REACTIVITY:
This chemical is incompatible with acids, iodine, heavy metal salts
and many alkaloids [295,455]. This chemical can be absorbed by rubber caps.
It is incompatible with strong oxidizing agents and strong bases. The rate
of oxidation for this compound is greatly increased by traces of copper ions
[295].
*STABILITY:
This chemical is stable in air, but not sunlight [033,233]. It may
discolor on exposure to light [269]. Dilute aqueous solutions of this
chemical are fairly stable to heat but labile to light. Solutions are less
stable to heat when acidic than when alkaline. Solutions are most stable to
light at pH 5 to 7. Solutions are unstable to heat but not to light in the
presence of copper, iron or zinc ions but not in the presence of calcium or
magnesium ions [295]. Solutions of this chemical in water, DMSO, 95% ethanol
or acetone should be stable for 24 hours when protected from light (RAD).
*OTHER PHYSICAL DATA:
pH of 1% aqueous solution: 6.7 [062]
Slight odor [062,295]
-TOXICITY
========
*NIOSH REGISTRY NUMBER: OV8400000
*TOXICITY: (abbreviations)
typ. dose mode specie amount units other
LD50 orl rat 75 mg/kg
LD50 scu rat 98 mg/kg
LD50 unr rat 40 mg/kg
LDLo ivn mus 30 mg/kg
LD50 orl mus 91 mg/kg
LD50 ipr mus 54 mg/kg
LDLo ial chd 60 mg/kg/4W-I
*AQTX/TLM96: Not available
*SAX TOXICITY EVALUATION:
THR: Poison by ingestion, subcutaneous, intravenous and possibly other
routes. An experimental neoplastigen and teratogen. Experimental
reproductive effects.
*CARCINOGENICITY:
Tumorigenic Data:
TDLo: scu-rat 104 mg/kg (1Y-I)
*MUTATION DATA: Not available
*TERATOGENICITY: See RTECS printout for data
*STANDARDS, REGULATIONS & RECOMMENDATIONS:
OSHA: Federal Register (1/19/89) and 29 CFR 1910.1000 Subpart Z
Transitional Limit: PEL-TWA 0.01 mg(Hg)/m3; Ceiling Limit 0.04 mg(Hg)/m3
[015,327,545,610]
Final Limit: PEL-TWA 0.01 mg(Hg)/m3 (skin); STEL 0.03 mg(Hg)/m3 [015,
545,610]
ACGIH: TLV-TWA 0.01 mg(Hg)/m3 (skin); STEL 0.03 mg(Hg)/m3 [610]
NIOSH Criteria Document: None
NFPA Hazard Rating: Health (H): None
Flammability (F): None
Reactivity (R): None
*OTHER TOXICITY DATA:
Skin and Eye Irritation Data:
eye-rbt 8 ug MLD
Status: EPA Genetox Program 1988, Positive: S cerevisiae gene conversion
EPA TSCA Chemical Inventory, 1986
Human lethal dose: 2-4 grams [301]
-OTHER DATA (Regulatory)
=======================
*PROPER SHIPPING NAME (IATA): Mercury compounds, solid, n.o.s.
*UN/ID NUMBER: UN2025
*HAZARD CLASS: 6.1 SUBSIDIARY RISK: None PACKING GROUP: III
*LABELS REQUIRED: Keep away from food
*PACKAGING: PASSENGER: PKG. INSTR.: 619, Y619 MAXIMUM QUANTITY: 100 kg, 10 kg
CARGO : PKG. INSTR.: 619 MAXIMUM QUANTITY: 200 kg
*SPECIAL PROVISIONS: None
*USES:
This compound is used as an ophthalmic preservative, a topical anti-
infective and a topical veterinary antibacterial and antifungal agent. It is
also used as a bacteriostat and a fungistat. It is an FDA over-the-counter
drug.
*COMMENTS: Not available
-HANDLING PROCEDURES
===================
*ACUTE/CHRONIC HAZARDS:
This compound is toxic by ingestion and inhalation [062]. It is an eye
irritant. When heated to decomposition it emits very toxic fumes of mercury,
sodium oxide and sulfur oxides [043].
*MINIMUM PROTECTIVE CLOTHING: Not available
*RECOMMENDED GLOVE MATERIALS:
GlovES+ Expert System Glove Types For The Neat (Undiluted) Chemical:
This chemical has not been tested for permeation by Radian Corporation;
however, the GlovES+ expert system was used to extrapolate permeation test
information from compounds in the same chemical class. The GlovES+ system uses
permeation data from literature sources; therefore, extra safety margins should
be used with the estimated protection time(s). If this chemical makes direct
contact with your glove, or if a tear, puncture or hole develops, replace them
at once.
The GlovES+ expert system is a tool that can help people better manage
protection from chemicals, however this tool cannot replace sound judgment nor
make technical decisions. Our GlovES+ expert system is designed to offer
initial advice and assistance in glove selection while the final glove
selection should be made by knowledgeable individuals based on the specific
circumstances involved.
Glove Type Model Number Thickness Estimated Protection Time
Natural rubber Edmont 36-124 0.51 mm 240 min
Neoprene Edmont 29-865 0.51 mm 240 min
Nitrile Edmont 36-175 0.46 mm 240 min
PVC Edmont 34-100 0.20 mm 240 min
*RECOMMENDED RESPIRATOR:
Where the neat test chemical is weighed and diluted, wear a NIOSH-
approved half face respirator equipped with an organic vapor/acid gas
cartridge (specific for organic vapors, HCl, acid gas and SO2) with a
dust/mist filter.
*OTHER: Not available
*STORAGE PRECAUTIONS:
You should protect this compound from light and store it under
ambient temperatures.
*SPILLS AND LEAKAGE:
If you spill this chemical, you should dampen the solid spill material
with water, then transfer the dampened material to a suitable container. Use
absorbent paper dampened with water to pick up any remaining material. Seal
your contaminated clothing and the absorbent paper in a vapor-tight plastic
bag for eventual disposal. Wash all contaminated surfaces with a soap
and water solution. Do not reenter the contaminated area until the Safety
Officer (or other responsible person) has verified that the area has been
properly cleaned.
*DISPOSAL AND WASTE TREATMENT: Not available
-EMERGENCY PROCEDURES
====================
*SKIN CONTACT:
IMMEDIATELY flood affected skin with water while removing and isolating
all contaminated clothing. Gently wash all affected skin areas thoroughly
with soap and water.
If symptoms such as redness or irritation develop, IMMEDIATELY call a
physician and be prepared to transport the victim to a hospital for treatment.
*INHALATION:
IMMEDIATELY leave the contaminated area; take deep breaths of fresh air.
IMMEDIATELY call a physician and be prepared to transport the victim to a
hospital even if no symptoms (such as wheezing, coughing, shortness of breath,
or burning in the mouth, throat, or chest) develop.
Provide proper respiratory protection to rescuers entering an unknown
atmosphere. Whenever possible, Self-Contained Breathing Apparatus (SCBA)
should be used; if not available, use a level of protection greater than or
equal to that advised under Respirator Recommendation.
*EYE CONTACT:
First check the victim for contact lenses and remove if present. Flush
victim's eyes with water or normal saline solution for 20 to 30 minutes while
simultaneously calling a hospital or poison control center.
Do not put any ointments, oils, or medication in the victim's eyes without
specific instructions from a physician.
IMMEDIATELY transport the victim after flushing eyes to a hospital even if
no symptoms (such as redness or irritation) develop.
*INGESTION:
Some heavy metals are VERY TOXIC POISONS, especially if their salts are
very soluble in water (e.g., lead, chromium, mercury, bismuth, osmium, and
arsenic). IMMEDIATELY call a hospital or poison control center and locate
activated charcoal, egg whites, or milk in case the medical advisor recommends
administering one of them. Also locate Ipecac syrup or a glass of salt water
in case the medical advisor recommends inducing vomiting. Usually, this is
NOT RECOMMENDED outside of a physician's care.
If advice from a physician is not readily available and the victim is
conscious and not convulsing, give the victim a glass of activated charcoal
slurry in water or, if this is not available, a glass of milk, or beaten egg
whites and IMMEDIATELY transport victim to a hospital.
If the victim is convulsing or unconscious, do not give anything by mouth,
assure that the victim's airway is open and lay the victim on his/her side with
the head lower than the body. DO NOT INDUCE VOMITING. IMMEDIATELY transport
the victim to a hospital.
*SYMPTOMS:
Symptoms of exposure to this class of compounds includes aphthous
stomatitis, catarrhal gingivitis, nausea, liquid stools, pain, liver dis-
order, injury to the cardiovascular system and hematopoietic system, deafness
and ataxia. Exposure may be fatal. Headache, paresthesia of the tongue,
lips, fingers and toes, other non-specific dysfunctions, metallic taste,
slight gastrointestinal disturbances, excessive flatus and diarrhea may occur.
Acute poisoning may cause gastrointestinal irritation and renal failure. Early
signs of severe poisoning include fine tremors of extended hands, loss of side
vision, slight loss of coordination in the eyes, speech, writing and gait,
inability to stand or carry out voluntary movements, occasional muscle atrophy
and flexure contractures, generalized myoclonic movements, difficulty under-
standing ordinary speech, irritability and bad temper progressing to mania,
stupor, coma, mental retardation in children, skin irritation, blisters and
dermatitis [173]. Other symptoms include chorea, athetosis, tremors, convul-
sions, pain and numbness in the extremities, nephritis, salivation, loosening
of the teeth, blue line on the gums, anxiety, mental depression, insomnia,
hallucinations and central nervous system effects [301]. Exposure may also
cause irritation of the eyes, mucous membranes and upper respiratory tract
[269].
-SOURCES
=======
*SOURCES:
[015] Lewis, R.J., Sr. and R.L. Tatken, Eds. Registry of Toxic Effects
of Chemical Substances. On-line Ed. National Institute for
Occupational Safety and Health. Cincinnati, OH. OV8400000.
March 8, 1990.
[029] Buckingham, J., Ed. Dictionary of Organic Compounds. 5th Ed. and
Supplements. Chapman and Hall. New York. 1988. Vol. 5, p. 5341,
#T-02044.
[033] Budavari, Susan, Ed. The Merck Index. 11th Ed. Merck and Co., Inc.
Rahway, NJ. 1989. pp. 1467-1468, #9244.
[043] Sax, N.I. and Richard J. Lewis, Sr. Dangerous Properties of Industrial
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Vol. III, p. 2205, #MDI000.
[058] Information Handling Services. Material Safety Data Sheets
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#1954-022, A-13.
[062] Sax, N.I. and R.J. Lewis Sr., Eds. Hawley's Condensed Chemical
Dictionary. 11th Ed. Van Nostrand Reinhold. New York. 1987.
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[082] U.S. Environmental Protection Agency, Office of Toxic Substances.
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Edition. 5 Vols. U.S. Environmental Protection Agency.
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[099] Grant, W. Morton, M.D. Toxicology of the Eye. 3rd Ed. Charles
C. Thomas, Publisher. Springfield, IL. 1986. p. 902.
[110] Oak Ridge National Laboratory. Environmental Mutagen Information
Center (EMIC), Bibliographic Data Base. Oak Ridge National
Laboratory. Oak Ridge, TN. Listed.
[120] Oak Ridge National Laboratory. Environmental Teratogen Information
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Laboratory. Oak Ridge, TN. Listed.
[151] Gosselin, R.E., H.C. Hodge, and R.P. Smith. Clinical Toxicology
of Commercial Products. 5th Ed. Williams and Wilkins, Co.
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[165] Wiswesser, W.J., Ed. Pesticide Index. Entomological Society
of America. College Park, MD. 1976. p. 146.
[173] Hayes, W.J., Jr. Pesticides Studied in Man. Williams and
Wilkins. Baltimore. 1982. pp. 20-23.
[195] Estrin, F.E., P.A. Crosley and C.R. Haynes, Eds. CFTA Cosmetic
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Fragrance Assn. Inc. Washington. 1982. p. 317.
[205] Dean, John A., Ed. Lange's Handbook of Chemistry. 13th Ed.
McGraw-Hill Book Company. New York. 1985. p. 7-401, #e286.
[233] Wardell, J.L., Ed. Organometallic Compounds of Zinc, Cadmium and
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[269] Lenga, Robert E. The Sigma-Aldrich Library of Chemical Safety Data.
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[275] Aldrich Chemical Company. Aldrich Catalog/Handbook of Fine
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[295] Reynolds, James E.F., Ed. Martindale The Extra Pharmacopoeia. 28th Ed.
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[415] American Conference of Governmental Industrial Hygienists.
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for 1988-1989. American Conference of Governmental
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[421] American Conference of Governmental Industrial Hygienists.
Documentation of the Threshold Limit Values. 5th Ed.
American Conference of Governmental Industrial Hygienists.
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[545] Office of the Federal Register National Archives and Records
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Not listed.
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