- BattleToads (NES) must be mentioned. Pick any level, they are ALL painful. Probably the hardest of any of the coin-op beat-up (Include TMNT and the Simpsons)
- Mario Kart (SNES). 150cc Special Cup. Rainbow Road. How many times did I get knocked over the edge?
- Advance War (GBA). Last Stage: Final Battle.
Those are the top three off of the top of my head. I almost want to mention the original Ninja Gaiden and Tyson wasn't that easy in Punchout but I think that these are the hardest one. (And look, I didn't even mention Pokemon).