Please post your corrections or questions about the old exam questions here.

Thanks,
Erin

Although Erin's already emailed it, make the following changes to the Pharm key:

For the HYPNOTICS/ANXIOLYTICS section, change number 10 to B.

For the DRUG/DEPENDENCE section, make the following changes: 8=D, 24=E, 25=B, 27=D.

Here are a few more:

Sulfonamides: #24=A
Aminoglycosides: #3=D #5=D
Antiepileptics: #15=C (and just forget about #6 - it's outdated and not a good test question)
Antipsychotics: #16=D

Also in Antipsychotics:

8=A
12=B
16=D

I think the correct answer is as it was: E.

My argument:
A. From the notes: "At appropriate doses, clozapine does not appear to antagonize the antiparkinson effect of levodopa..."
B. Lippincott's p131 part 3 - drowsiness occurs
C. Lipp p128 part 2 - clozapine has affinity for D4
D. Lipp p132 - fig 13.8 - agranulocytosis in up to 2%

So the answer is all of the above, E.

Thanks, Michael!!! I totally missed that one - I was falling asleep when I went through that exam. Aghhhh!!!

Louis caught another one:
Antifungals: 8=C

Thanks,
Erin

General anaesthetics--#1 should be B --because a high potency drug would have a high MAC (not a low one). MAC also describes the potency of a drug (not % of the drug in the inhaled gas mix).

Anti-Parasitics-- #9 should be C. The antimalarials causing acute hemolysis in G6PDH deficient individuals are quinine and chloroquine, not primaquine.

Regarding Anesthetics #1: according to Lipp p111, "MAC is small for potent anesthetics, such as halothane, and large for less potent agents, such as nitrous oxide." B isn't the answer.

Lipp also says that MAC "is usually expressed as the percent of gas in a mixture required to achieve the effect."

General anaesthetics--#1 should be B --because a high potency drug would have a high MAC (not a low one). MAC also describes the potency of a drug (not % of the drug in the inhaled gas mix).

Anti-Parasitics-- #9 should be C. The antimalarials causing acute hemolysis in G6PDH deficient individuals are quinine and chloroquine, not primaquine.

Excerpts from the lecture notes:

"People who are primaquine sensitive have a genetically determined deficiency of glucose-6-phosphate dehydrogenase (G6PD) in their erythrocytes."

"In certain patients, quinine may cause the dreaded syndrome, 'blackwater fever'...Glucose-6-phosphate dehydrogenase deficiency may be an important etiologic factor of this syndrome."

Primaquine is also listed in First Aid p297 for hemolysis in G6PD-deficient patients.

Antiparasitic #9 should still be B.

I agree with Michael about General Anesth #1 and Antiparasites #9 being correct as marked 'cause I looked at those myself.

I do think, however, that in Headache #12 should be A.
Ergotamine is used for treatment of cluster HA (both episodic and chronic) and methylsergide is for prophylaxis.

Of course, it's 1.75hrs until the exam so none of you may care anymore.

That was right before I went to sleep that night, which was probably a good thing--too many hrs of cramming was making me kinda stupid :) --Maggie