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Message board for narcoleptics, friends and family. Ask/answer questions...or just get it off your chest.

more on orexin Alzheimer’s

by phil (no login)

Amyloid-β Dynamics Are Regulated by Orexin and the Sleep-Wake Cycle
Jae-Eun Kang,1 Miranda M. Lim,1 Randall J. Bateman,1,2,3 James J. Lee,1 Liam P. Smyth,1 John R. Cirrito,1,2 Nobuhiro Fujiki,4 Seiji Nishino,4 David M. Holtzman1,2,3,5,*

Amyloid-β (Aβ) accumulation in the brain extracellular space is a hallmark of Alzheimer’s disease. The factors regulating this process are only partly understood. Aβ aggregation is a concentration-dependent process that is likely responsive to changes in brain interstitial fluid (ISF) levels of Aβ. Using in vivo microdialysis in mice, we found that the amount of ISF Aβ correlated with wakefulness. The amount of ISF Aβ also significantly increased during acute sleep deprivation and during orexin infusion, but decreased with infusion of a dual orexin receptor antagonist. Chronic sleep restriction significantly increased, and a dual orexin receptor antagonist decreased, Aβ plaque formation in amyloid precursor protein transgenic mice. Thus, the sleep-wake cycle and orexin may play a role in the pathogenesis of Alzheimer’s disease.

Posted on Nov 12, 2009, 3:34 PM

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Re: more on orexin Alzheimer’s

by (Login patlittlejohn)
Moderators

If I were a mega-pharm company, watching 2 or 3 years of Narkorex trials,

and i wanted to "fuel" its importance plus enhance profitability,


i might want this connection to become big news right about now.

Posted on Nov 18, 2009, 5:12 AM

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strep 0602 vs 0301

by phil (no login)

Rheumatic fever (RF) classically occurs after group A Streptococcus (GAS) pharyngitis in children aged over 5 years in developing countries. The present report describes the bacterial and host determinants in non-related toddlers who developed RF diagnostic criteria after toxic shock syndrome (TSS).

Methods and results
A 13-month-old boy and a 14-month-old girl presented GAS TSS. After several weeks, multiple subcutaneous nodules as well as migratory polyarthritis or monoarthritis developed in both children, fulfilling Jones criteria of RF. The relevance of the Jones criteria for very young children is, however, debatable and their use might lead to the unnecessary prescribing of secondary prophylaxis. A molecular analysis of both bacterial and host factors was carried out in an attempt to decipher the combination that could have led to such uncommon, but very similar presentations. The two GAS isolates belonged to the usual, although distinct, invasive emm-types 1 and 3. Both isolates carried a wide set of prophage-encoded virulence factors, with only the speG and speA superantigen-encoding genes in common. Both patients shared the HLA DQB1*0301 allele, which has been associated with susceptibility to GAS necrotizing fasciitis.

Posted on Nov 11, 2009, 4:22 PM

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re

by phil (no login)

The Strep SAgs include the streptococcal pyrogenic exotoxins (Spes), which play a crucial role in the pathogenesis of severe invasive streptococcal diseases, including Strep toxic shock syndrome (STSS). However, not all septic individuals infected with SAg producing GAS develop STSS. Our epidemiologic studies showed that individual HLA class II allelic variation play a crucial role in modulating the severity of invasive GAS diseases. Certain HLA class II alleles and haplotypes confer strong protection from STSS (DRB1*1501/DQB1*0602)

Posted on Nov 11, 2009, 9:47 PM

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email hacked

by (Login patlittlejohn)
Moderators




some piece of trash went out from my email account yesterday.



I have my own email address on my contacts list, and i am sorry this did not seem odd to me right away yesterday. there were two dates that i received them, i assume everyone on my list did, too.

Posted on Nov 11, 2009, 8:30 AM

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Re: email hacked

by Melody (no login)

Not yet.. but will keep an eye out for it. Sorry it had to happen to you as well.

Posted on Nov 11, 2009, 11:54 AM

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Tramadol

by phil (no login)

Emerging drugs for narcolepsy.

Abad VC, Guilleminault C.

Clinical Monitoring Sleep Disorders Center, Camino Medical Group, Cupertino, California, USA.

Narcolepsy is characterised by excessive daytime sleepiness, usually associated with cataplexy, hypnagogic hallucinations, sleep paralysis and fragmented nocturnal sleep. Although uncommon, it results in significant disability. Most cases occur sporadically, but genetic factors probably form a susceptibility background on which unknown environmental triggers act. The hypocretin system is strongly implicated in the development of narcolepsy. Cerebrospinal fluid levels of hypocretin-1 are significantly reduced in narcoleptic subjects with cataplexy. Despite the advances in our understanding of narcolepsy, current therapy is primarily symptomatic. Stimulants (standard and novel) combat excessive daytime sleepiness. Antidepressants (tricyclics, dual-action or selective serotonin re-uptake inhibitors) and sodium oxybate are anticataplexy agents. Hypnagogic hallucinations and sleep paralysis respond to antidepressants. Sodium oxybate consolidates sleep. Novel and experimental treatments include histamine antagonists, hypocretin agonists, slow-wave sleep enhancers, intravenous gamma-globulin, tramadol and corticosteroids.



Tramadol is not considered a controlled substance in the US and Canada, and is available with a normal prescription. Tramadol is available over the counter without prescription in a few countries

Structurally, tramadol closely resembles a stripped down version of codeine. Both codeine and tramadol share the 3-methyl ether group, and both compounds are metabolised along the same hepatic pathway and mechanism to the stronger opioid, phenol agonist analogs. For codeine, this is morphine, and for tramadol, it is the M1 metabolite, O-desmethyltramadol. The closest chemical relative of tramadol in clinical use is Venlafaxine (Effexor), the SNRI. The two molecules are nearly identical. Both tramadol and Venlafaxine share SNRI properties, while Venlafaxine is devoid of any opioid effects.



Although not related to traditional opioids, tramadol can produce a very pleasant high in many users. At high but therapeutic single doses (about 75–200 mg), the high is similar to opioids, but not as intense. Many recreational users state that tramadol induces euphoria and a state of well-being without clouding and muddling thinking like other opioids (hydrocodone, morphine, etc). The effects of tramadol are also noted to last longer than that of opioids. For example; effects from hydrocodone last 4 to 6 hours, while those of tramadol can last up to 8 or 12. The high brought on by tramadol may not be just from its weak opioid activity, but also from its sudden action on serotonin and norepinephrine, which may explain the stimulant-like effects.


Posted on Nov 10, 2009, 3:44 PM

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Re: Tramadol

by (Login patlittlejohn)
Moderators

Thanks Phil, i am looking into this further.

Posted on Nov 11, 2009, 8:39 AM

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Re: Tramadol

by Melody (no login)

Tramadol is what I took when I was in the UK when my back went out. The neighbor downstairs had some and gave me the bottle. Not only did it help the pain immensely.. I was AWAKE. I had energy and felt AWAKE. Only problem was.. when it started to wear off around 5 or 6 pm.. I would get a terrible headache. I admit, I took all of them.. lol.. but because of the headaches was not that sorry to stop them.

Posted on Nov 11, 2009, 12:00 PM

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re: tramadol

by (no login)

Just remember that tramadol, should never be taken with alcohol. It can have deadly affects. Tramadol is habit forming, memory loss can be significant and easy to overdose, because alot of people forget how much they have taken. It should be taken with extreme caution. We had many an overdose in the ER from people taking tramadol. Just be cautious.

Posted on Nov 13, 2009, 10:24 AM

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tramadol and SSRIs

by (no login)

Just be careful if you are on any SSRIs, such as Zoloft - co-administration can lead to serotonin syndrome.

Posted on Nov 18, 2009, 7:25 PM

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RX

by Lynne (no login)

I can't get any of my meds anymore, including the ritalin...because i can't go in to see the doctor without insurance. So i did a bad thing, i accepted some sleeping pills that someone in my family was not using. It is the one called Rozerem.

I just want to say they are awesome and work almost as good as Xyrem for me. They are supposed to be prescribed for insomnia, but most people blogging or writing comments about the drug do not like it. Lots of them say it is keeping them in a 1/2 sleep state, or giving them nightmares, or making them groggy the next day. Perhaps because it should be prescribed for narcolepsy instead. I hardly dream at all on them, and they put me to sleep for almost 4 hrs. and i am not groggy the next day. If i could take 2 per night, it would be basically like xyrem for me.

I only had 12 of them though, and took one per night...Too bad i only have one left...boohoo.

Posted on Nov 9, 2009, 5:35 PM

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Re: RX

by Lindsay (no login)

My doc tried me on rozerem. I don't like it. I sleep good with it-- but it's even harder to wake up. And if I wake up before the meds wear off or whatever is keeping me asleep, I am really groggy/ foggy/ whatever...even more than just narcolepsy.

Posted on Nov 9, 2009, 6:39 PM

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Re: RX

by Lynne (no login)

did you make sure you had at least 8 hrs. to sleep? because i had a few days where i didn't sleep 8 hrs. and i was pretty groggy until i took a nap. the days i actually slept 8 hrs. the next day i felt pretty good.

Posted on Nov 10, 2009, 9:42 AM

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Re: RX

by Lindsay (no login)

Yeah I had plenty of time to sleep. When I took them, I slept for like 12 to 14 hours or more. There may have been other factors- I can't seem to remember that far back right now. I would take them around nine so they would kick in for ten and then I'd sleep until one, two, three in the afternoon. Didn't seem to work for me lol They didn't make me tired, either. Unless I made myself go to bed at 10 I could stay awake most of the night.

Maybe they just didn't work? lol I don't know! It just seemed like they didn't feel like they were working until I was "supposed" to wake up... and then I just couldn't. Like, I couldn't even be roused.

Posted on Nov 15, 2009, 3:26 PM

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Left out of the bundle!

by (no login)

Is it me or is every other disorder/condition getting way more recognition than ours(N).
From Parkinsons to Tourettes to Sleep Apnea to Epilepsy to all others but Narcolepsy.
Very fustrating i think!

Could i represent us i would.

I'm talking about radio chat shows and guest speakers for organizations.ect
Tv, internet, brochures in doctor surgeries, magazine articles, newspapers.

I speak from an Australian perspective. Do u agree with what i am saying or??
What can we do to get it out there to the public.

If someone could write a great story worth making a hollywood movie out of would be great, but i have my doubts on that because of the lack of action or drama to a Narcolepsy story nah mean!

Or a Bono or rockstar/rockband speaking out for us.

I absoltely hate the fact that we have what i consider to be a totally debilitating condition that is seen at first sight/thought as a lightweight disorder!

As we have said many times before,it goes way beyond just the eds symptom! and should not be defined by just that.

Sure that dude outta Greys Anatomy show has spoken out about his friend but i wouldn't have even heard that if i didn't get sent a link from a N related friend or group!

How can we be heard like other disorders to get that recognition the rest are getting more and more of.???

Cheers!


Posted on Nov 9, 2009, 3:49 PM

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Re: Left out of the bundle!

by Lynne (no login)

yeah, its like everyone and their brother have sleep apnea, but not a single person i know or seen in my life has narcolepsy.

Posted on Nov 9, 2009, 5:36 PM

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Take up the bundle

by (no login)

You need to connect with Pam. She has a program that she has put together that she takes to schools.
Pam has printed material that goes with her talk. This may not be what you had in mind, but it is a place to get your foot in the door. We have a local talk show on AM radio. I have called in and talked about having N. 3 or 4 times. It may not be much but it can help.
GEM, Oregon

Posted on Nov 9, 2009, 7:23 PM

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Re: Take up the bundle

by (no login)

Thats great what Pam is doing, what a legend! much respect.
I'd love to do something similar one day, but at the moment i am not up for it.
I am not the best speaker ect...
I am in Australia once again.
Bit far from most of you all.

Mabye i will step up and push for a loud voice to be heard in my area.
And call up on Am radio when appropriate.

We should all be thinking of ways to do get our story out there, whatever that might be!

Laterz.
Ev


Posted on Nov 11, 2009, 3:48 AM

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Sleepy crusaders

by (Login patlittlejohn)
Moderators

Ev, i think you are right. When my legal champion, Matt Garris was alive, I could tag along with him into advocacy quite a bit. now with my husband in ministry, that is where i can do most of my "alert" work.

About N, i am most likely to say little; it just always feels like i am a big walking excuse, and trying to be as well spoken as Mali Einen was on the radio, is really difficult.

Posted on Nov 11, 2009, 8:45 AM

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re: Left out of the bundle

by (no login)

Thanks to Gem for that pat on the back. But this is all so important to me to get out the information about N and get kids dx sooner than my 33 years. Starting with the school counselors and school nurses is a beginning. As more are DX early the more the message will get out. I wrote to Dr. Oz and requested that he do a segment on Narcolepsy, haven't heard back this past week. National television is a good medium, we just need to keep plugging away. I have given out over 100 Narcolepsy pamphlets in my RV park to friends that I participate with in activities. They are pretty well educated at this point and have witnessed my EDS and many episodes of falling to the floor cataplexy, so they have a much more graphic picture of what our symptoms are like on a daily basis. I vowed that I was not going to be such a recluse this year and dispite the embarrassment get out and participate, even if I can't be as normal as the rest. If I have to stop in the middle of cards and go home and take a nap, so be it, they all just have to deal with it. We are just the few that have this invisible disorder and it's hard to see and explain. Our educators are just not educated when it comes to N and that includes the majority of physicians. They are just at loss for words! I've mentioned before about a movie on LMN that aired a few months ago called "Wide Awake", the story was about a narcoleptic, the actress did a fantastic job, in my opinion, of playing a narcoleptic. I'll let you all know when it comes on again.

Posted on Nov 13, 2009, 10:15 AM

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tell me

by phil (no login)

my internet is too slow tell me about the Mali interview


http://www.narcolepsynetwork.org/?page_id=34

Posted on Nov 8, 2009, 12:49 PM

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rough transcript

by (Login patlittlejohn)
Moderators



M: mali described what n is.

M: discussed the impact on young adults, progressive autoimmune nature,

M: likened it to diabetes and crohn's

M: most commonly occurring (first) in young adults, teens and early twenties.

M: commonly goes undiagnosed.

M: 5 main symptoms, mostly 4 of those happen to normal people, but infrequently. all 5 happening all the time are indicators:


M: falling asleep ... reading, on the bus, listening to music, watching tv, profound and overwhelming.

M: cataplexy... this does not occur in normal people.

M: vivid dreams

M: disrupted nighttime sleep

sorry, I missed one, i think it was hallucination



Interviewer asked, "are you conscious of the paralysis during sleep?"

M: Like being caught halfway between sleep and waking, semi conscious. during REM normal people are paralyzed... this happens when our mind is awake but our body is stuck in REM

"do you come out of that?"

M: yes, but hard to judge how long that takes.

M: sometimes it helps if someone touches you or tries to wake you.

M: for normal people with sleep deprivation this can happen, too.

"are there many cases of n?"

M: probably 1 in 200,000 people are missing this hypocretin in the brain. maybe more people have milder versions, with something like mild diabetes, pre diabetic conditions,


"what should we do if we think we have it?"

M: first recognize it. with kids in sleep dep, it might be hard to distinguish. problems falling asleep inappropriately might send you to the doctor.

M: some other conditions like thyroid or anemia might mimic, but go to the doctor.

M: it might be commonly overdiagnosed as depression.

M: medications have been proved over the years: stimulants for students of people with repetitive work.
M: for c, antidepressants actually work.
M: xyrem seems to address all symptoms. has seen great successes in kids/students

M: taking naps, etc.

M: n does not mean you need more sleep, but trying to get enough of the right sleep at teh right time.

"support systems for n: ?"

M: its an important part, because n is for life. at different stages of life we need different kinds of support or advice. ref n network, newsletter, answer emails, etc.

M: often people who are not dx are underemployed, and have trouble in life.

M: when I got on the right med I got my life back again.

M: N network conference, scholarships to attend,

M: they have a list of local support groups, to connect with someone closeby, sometimes helps to meet someone with the same challenges.
also online support, message boards, chat

"do you have N?"

M: yes, i worked in finance, not medicine. i was lucky to be dx quickly, the time has come down from about 14 years to be dx.

M: people will say we are just lazy or fall asleep all the time, an invisible disorder.

"what about research?"

M: in 2000 discovery of hypocretin made researchers interested;
M: HLA marker seems to be an inherited likelihood.

M: made pwn want to be part of the research.

"Going on for 14 years before dx, dealing with docs and testing must be a long process"

M: people make assumptions for so long, it gets ignored at first. if the doc doesnt support you and refer you appropriately, thats difficult. insist on another opinion, and use the word "sleepy", not "tired".

"Doc has to refer you to specialists?"

M: Pcp can refer, or some insurance lets you go directly to the specialists. ask your insurer, or the docs office. most docs will refer you.

"what research have you done about african americans?"

M: greater numbers of blacks have the gene, but fewer proportions have n.

M: in my experience and research, i noticed and asked Mignot why someone with all the same measured symptoms the same, does not have c?

M: she said maybe 50 percent of blacks with n do not have c.

M: harder to get dx.

M: those black pwn i have met who have and do not have c, respond differently to challenge than culturally different caucasion and other data.
or it might be a gene that protects from c.

M: i can recruit people in the research, and it might help them and the greater group.

"what about these 100 black participants, often studies are done, and the white population is more into participating, is key, we need to participate"

M: there are subtle diff's, we had a korean study, by a korean doc, and there are subtle diff's that may help people of that background, might customize treatments, and also open a new discovery in general.

M: to inquire, with or w/o dx, contact Mali.
unpaid (participation) but it will not cost the subject for blood test submissions.

800 497 5337
einen@stanford.edu


M: talked about challenges in school and work. there is help; medications do help quite a bit.


"anything you would like to say?"

M: if you have n, the tendency is to let their world get smaller and smaller. i want everybody with n to be the person they were meant to be, and dont become isolated. with the right dx and the right treatment, we can live more full rich lives. dont ignore it, dont listen to stereotypes or judgments.




Posted on Nov 8, 2009, 2:04 PM

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Facebook

by Lindsay (no login)

I deleted my old profile because I had flooded it with FB games people. Please readd me :)


www.facebook.com/lawropiak

Posted on Nov 7, 2009, 11:09 PM

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I dont care anymore!

by Scarlet (no login)

I don't care if people think I am abusing adderall- I am going to keeep taking it. Their opinion means nothing to me- I am going to take it in a few hours so I can stay awake for my sons football game!!


Who cares what the rest of the world thinks!

Posted on Nov 6, 2009, 9:15 AM

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Re: I dont care anymore!

by (Login patlittlejohn)
Moderators

Dear Scarlet,



I KNOW: we kind of got that kind of caring kicked out of us.

Sure we could stand in a pharmacy or ER with our heads hanging down, listening to

THIS IS A VERY DANGEROUS AND CONTROLLED DRUG,

WE KNOW "DRUG SEEKING BEHAVIOR" WHEN WE SEE IT,

JUST LET ME CALL THE DOCTOR, AND PROVE YOU REALLY NEED THIS,

OH, "NARCOLEPSY", SO THAT'S YOUR EXCUSE!



I was very lucky to get relief with provigil for a while, because mostly people had never heard of it.






Honey, that train left the station years ago (about the time we started losing everything meaningful and precious)...

If they want us to hang our heads now, they will have to find something we have not lost yet.

Posted on Nov 7, 2009, 9:17 AM

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GEM Knife Boxes

by Bulldawg (no login)

Hey GEM

Did you get your knife display boxes done?

Posted on Nov 5, 2009, 3:07 AM

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99 and 44/100%

by (no login)

I have been thinking about you, but with everything on your plate lately, I did not want to bother you. I have had so little chance to spend out in the shop I was not sure I was going to get them done. I ended up doing them all the same since it would be fastest. I completed them yesterday, with a little finishing left. So your timing was right on. Send your E-mail to:
ggbellringer@yahoo.com I may have to get help to send the pictures but will send them when I can.

GEM

Posted on Nov 5, 2009, 8:15 AM

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Fart Tax

by phil (no login)

WELLINGTON - New Zealand farmers are being asked to cough up NZ$8.4 million (2.9 million pounds) a year to help reduce greenhouse effects caused by flatulence of their millions of sheep and cattle -- and they say the plan stinks.

Last year New Zealand signed up to the Kyoto Protocol (news - web sites) on global warming (news - web sites) and agreed to reduce production of greenhouse gases which are suspected of being a major cause of climate change.

Now the government plans to introduce a tax to help pay for research into livestock emissions of methane and nitrous oxide, which account for more than half of the country's greenhouse gases.

But farmers argue that reducing greenhouse gas emissions benefits everyone so the costs should be spread across all taxpayers.

"This decision is yet another example of the government's desire to act in the wider public interest but expecting rural New Zealand to pay for its largesse," Federated Farmers President Tom Lambie said.

Most of the livestock emissions come from the methane-rich burps of cows and sheep.

On current livestock numbers of around 46 million sheep and nine million cows, the levy will cost farmers around nine cents a sheep a year, and around 72 cents per cow.

Deer and goats will also be taxed, but pigs and poultry -- paltry contributors to greenhouse emissions by comparison -- are exempted.



Posted on Nov 4, 2009, 12:20 AM

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Gas Tax

by GEM (no login)

Watch out for the Flatulence Cops.

Posted on Nov 4, 2009, 6:54 AM

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global warming

by (no login)

I've noticed 'Global Warming' is now called 'Climate Change'...what 'they' don't want ot acknowledge is the fact that climate change is normal and runs in cycles. In the 70's it was 'Global Cooling' Time magazine reported the world was headed toward another ice age. The so called scientists said it was due to pollution. In the 90's the so called scientists said the world was headed in the opposite direction...due to pollution. Now, here we are in the 21st century and finding out is neither. The drafters of the Kyoto Protocol have fart gas for brains.

Besides, what will money in the coffers of the UN do to stop climate change? Just another tax to fund the Machine.

Posted on Nov 5, 2009, 11:30 AM

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re

by phil (no login)

the whole fart tax thing makes me roll on the floor laughing

Posted on Nov 5, 2009, 8:21 PM

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OOOPS Just Got fined $10 on the Fart Tax

by Bulldawg (no login)



Posted on Nov 6, 2009, 1:06 PM

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Pitutary Tumor

by Bulldawg (no login)

Does anybody have information on pitutary tumors? Odds are I might have one. MRI scheduled Monday week.

Posted on Nov 2, 2009, 10:53 AM

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prolactinoma

by phil (no login)

I have a friend that has a prolactinoma
depends on how long you have had it how removeable it is
wheter or not cancerous
options surgery, radiation

the person I know is still alive five years later

Posted on Nov 2, 2009, 8:58 PM

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Re: prolactinoma

by (Login patlittlejohn)
Moderators

Bulldawg,

Keep the faith, Dear. I think that is what my close friend had back in the mid 90's and he is completely well.

We are praying for you.




Posted on Nov 3, 2009, 6:00 AM

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what

by phil (no login)

what got you here symptoms, blood test ?

Posted on Nov 3, 2009, 10:45 AM

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What got me here

by Bulldawg (no login)

After much blood work (one such test was drawn by Vald the Impeller's wife)testestrone level low all other levels normal which is abnormal that they are normal. The endocrinologist wants to do a MRI on my brain. I've looked on the internet and its says that a tumor might be the culprit. other symptoms include:

Sllep Apnea
Excess sweating
skin tags
colon polps
headaches
obesity in mid section (I always thought I had furniture disease. My chest fell in my drawers)
restless leg
HOT FLASHES AT NIGHT
Male menopause
depression
Decreased stamina
easly fatigued

Any thoughts?


Posted on Nov 3, 2009, 3:33 PM

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prolactin

by phil (no login)

did they check prolactin blood level

Autopsy studies indicate that 6-25% of the U. S. population have small pituitary tumors. Forty percent of these pituitary tumors produce prolactin, but most are not considered clinically significant. Clinically significant pituitary tumors affect the health of approximately 14 out of 100,000 people. In nonselected surgical series, this tumor accounts for approximately 25-30% of all pituitary adenomas. Some growth hormone (GH)–producing tumors also co-secrete prolactin. Microprolactinomas are much more common than macroprolactinomas

Hyperprolactinemia can cause reduced estrogen production in women and reduced testosterone production in men. Although estrogen/testosterone production may be restored after treatment for hyperprolactinemia, even a year or two without estrogen/testosterone can compromise bone strength

Posted on Nov 3, 2009, 7:01 PM

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? Age

by (no login)

I went to see my sleep Dr. on the 20th of Oct., a little over a month from my birthday. I had become curious about the life span of someone with N. He assured me that N. does not shorten our life span in any measurable way. Except for accidental death! We are more prone to accidents. (So be more careful) I told him that I was asking because I am now the oldest person that I know, that has N.
I have never worried about death, but this last birthday has been an obstacle. How due you except something (70) that has never registered in your memory bank. It can not be! In the mirror I may look it, I may be slower doing things, I bruise more often, But my mind still says "it can not be".
I guess as long as I can, I will still kick and fight as I am being drug into advanced age.
You have to pick and chose your battles, and you never want to give in!

Posted on Nov 1, 2009, 5:26 AM

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Happy birthday to GEM

by (Login patlittlejohn)
Moderators

This is such wonderful news~


btw, 70 in our two families is considered on the young side.

Bless you and your wife, and family. Celebrating with you all.

Posted on Nov 1, 2009, 8:51 AM

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jokes

by phil (no login)

HALLOWEEN SKELETON JOKES

--------------------------------------------------------------------------------


When does a skeleton laugh?
When something tickles his funny bone.

Why don't skeletons like parties?
They have no body to dance with.

Who won the skeleton beauty contest?
No body

What do skeletons say before they begin dining?
Bone appetite !

Why should a skeleton drink 10 glasses of milk a day?
It's good for the bones

Why didn't the skeleton cross the road?
He didn't have the guts.

What is a young skeleton?
A skeleteen

What do skeletons like to eat?
Ribs

Which skeleton is a famous comedian from yesteryear?
Red Skeleton

What do you call a stupid skeleton?
A numbskull

What is a skeleton's favorite insult?
The word 'Bonehead'

How does a skeleton get into his house?
With a skeleton key

What do skeletons have nightmares of?
Dogs

What forms of major education do skeletons attend?
High Skull

What did the skeleton get for killing a ghost?
2000 Bone-us points


Posted on Oct 27, 2009, 2:33 PM

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Re: jokes

by (Login patlittlejohn)
Moderators

giggles! we will be housesitting and are requested to give candy to the little nippers.

Posted on Oct 28, 2009, 12:45 AM

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Re: jokes

by (no login)

UGH!

Posted on Oct 28, 2009, 11:35 AM

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Pumpkins

by phil (no login)

Why Pumpkins Are Better Than Men
1. Every year you get a brand new crop to choose from.

2. No matter what your mood is, pumpkins are always ready to greet you with a smile.

3. One usually makes a better pie.

4. They are always on the doorstep there waiting for you!

5. If you don't like the way he looks, you just carve up another face.

6. If he starts smelling up your place, you can just throw him out.

7. From the start you know a pumpkin has an empty, mush filled head to begin with.

8. A pumpkin is turned on (lit-up) only when you want him to be.



Posted on Oct 30, 2009, 1:20 PM

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Re: Pumpkins

by Melody (no login)

LOL.. good ones, Phil.. Happy Halloween, everyone :).

Posted on Oct 31, 2009, 12:14 PM

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Latest to have email hacked

by (no login)

Seems I am the latest to have this happen. Luckily a couple in my address book, their address is no longer good so I got them back.. that's how I know something was sent out. Several in here are in that book.. so anything you receive from me can be deleted .. looks like all they sent out was a link.. and I'm hoping none of you clicked on it. A few of you know my main email address and those of you that don't and want it.. let me know. I apologize for any problem these idiots may cause.

Posted on Oct 20, 2009, 11:42 AM

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Re: Latest to have email hacked

by (Login patlittlejohn)
Moderators

i clicked and avast! caught it and terminated the connection.

please send me your other address, to littlejohnquilt at msn dot com.

Posted on Oct 20, 2009, 5:10 PM

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