http://www.baumhedlundlaw.com/media/timeline.htmlSome relevant extracts:
"7: Nov. 17, 1989 - Letter to sales representatives on article about Prozac-induced akathisia authored by Dr. Lipinski and others. "In the article the authors voice their suspicion that ‘the triad of symptoms' (anxiety, nervousness, and insomnia) reflects the syndrome of akathisia, ‘which, in their view is apparently related to fluoxetine (Prozac) therapy." But the sales people are warned: "Use of this information in product discussions may violate federal law." Exhibit 91 (1st page, 2nd paragraph and 2nd page, last sentence)"
...."29: December 1991 - Dr. Rothschild's Article "Re-exposure to Fluoxetine After Serious Suicide Attempts by Three Patients: The Role of Akathisia" - "This is the first report, to our knowledge, of patients restarted on fluoxetine (Prozac) after a previous suicide attempt during fluoxetine treatment." . . ."When re-exposed to fluoxetine, the patients again developed akathisia and suicidal ideation. The suicidal feelings abated when the akathisia was treated by the discontinuation of the fluoxetine (Prozac) or the addition of propranolol." Exhibit 131 (Cross-examination)"
....."35: June 1998 - Dr. Roger Lane's article "SSRI-Induced Extrapyramidal Side-Effects and Akathisia; Implications for Treatment" appears in the Journal of Psychopharmacology. "SSRI-induced akathisia is a relatively rare but is frequently unrecognized when it does occur." . . . "The precise definition of akathisia is a matter of controversy, as is the relative importance of the objective and subjective aspects of the disorder. Is akathisia a movement disorder or an intense and uncomfortable mental state . . ." "It may be less of a question of patients experiencing fluoxetine (Prozac)-induced suicidal ideation, than patients feeling that ‘death is a welcome result' when the acutely discomforting symptoms of akathisia are experienced on top of already distressing disorders."