Strattera (atomoxetine)
http://www.rxlist.com/cgi/generic3/strattera_ad.htm
"Reasons for discontinuation of treatment due to adverse events in child and adolescent clinical trials — In acute child and adolescent placebo-controlled trials, 3.5% (15/427) of atomoxetine subjects and 1.4% (4/294) placebo subjects discontinued for adverse events. For all studies, (including open-label and long-term studies), 5% of extensive metabolizer (EM) patients and 7% of poor metabolizer (PM) patients discontinued because of an adverse event. Among STRATTERA-treated patients, aggression (0.5%, n=2); irritability (0.5%, n=2); somnolence (0.5%, n=2); and vomiting (0.5%, n=2) were the reasons for discontinuation reported by more than 1 patient.
Commonly observed adverse events in acute child and adolescent, placebo-controlled trials — Commonly observed adverse events associated with the use of STRATTERA (incidence of 2% or greater) and not observed at an equivalent incidence among placebo-treated patients (STRATTERA incidence greater than placebo) are listed in Table 1 for the BID trials. Results were similar in the QD trial except as shown in Table 2, which shows both BID and QD results for selected adverse events. The most commonly observed adverse events in patients treated with STRATTERA (incidence of 5% or greater and at least twice the incidence in placebo patients, for either BID or QD dosing) were: dyspepsia, nausea, vomiting, fatigue, appetite decreased, dizziness, and mood swings (see Tables 1 and 2)..."
WARNING NOTE:
ELI LILLY,
IN THEIR PROZAC CLINICAL TRIALS,
USED THE WORD
"NAUSEA"
AS A CODE FOR INCIDENTS OF
HOMICIDALITY
and
SUICIDALITY
occurring in PROZAC clinical trials.
See reference to Professor David Healy's correspondence with the MHRA, in threads lower down on SSRIs.
http://www.rxlist.com/cgi/generic3/strattera_ad.htm
"...Animal Experience
Drug discrimination studies in rats and monkeys showed inconsistent stimulus generalization between atomoxetine and cocaine... "
So a bit like LOTS of modern mind altering meds then?
"...The efficacy of STRATTERA beyond 9 weeks and safety of STRATTERA beyond 1 year of treatment have not been systematically evaluated. .."
NINE WEEKS? But they know that psychs and others will keep prescribing anyway - and the drug is about PROFIT not people. SAFETY AFTER 1 year unknown? By then Lilly will have made millions, and the drug will be prescribed widely and become established, then there'll be years of adverse reports coming in and being denied....repeat of the Prozac situation (and LSD probably) both of which were also made by Eli Lilly who LIED about homicidality and suicidality occurring in their clinical trials of Prozac (and probably LSD, and probably Strattera - they haven't owned up to their Prozac lies yet so why would anyone trust them to have been honest about THESE trials?).
"[on Mutagenesis]...However, there was a slight increase in the percentage of Chinese hamster ovary cells with diplochromosomes, suggesting endoreduplication (numerical aberration). "
A try at translating that last paragraph into understandable language by guesswork, from a non scientist! :
Mutagenesis: Muta (mutate?) genesis (genetics?) ergo I guess mutating DNA/chromosomes.
In this case in the ovary of hamsters.
Diplochromosomes: chromosomes that have duplicated - rather like cells do in cancer?
So in the ovaries of mice, their cells were duplicating on Strattera. Mice don't live long. If it happens in humans who DO, then presumably cancer developing?
Would that be Ovarian cancer (the silent killer)?
Over time - long periods of medication, could that happen in other parts of the body too?
OR....
The DNA chromosomes in the ovaries mutating and duplicating. Maybe that means that when pregnant, the egg from the ovaries would mean that the mice foetus would be faulty, as in thalidomide? And so born with mutated limbs etc?
Whichever (or neither) it is, I believe the pharma industry should translate their 'findings' into CLEAR ORDINARY LANGUAGE so that ordinary people can IMMEDIATELY UNDERSTAND the risks??
Instead of disgusing serious issues in tiny paragraphs full of large sicentific words. They have plenty of scientific words, but their SCIENCE (as in knowing what the drugs do) is FLIMSY.
I think I need to "phone a friend" to see if my interpretations are on track or wildly wrong 