- Crinone works directly on the uterus but doesn't show up in the blood. So it is hard to monitor. So even though I was on Crinone, my blood progesterone test result was only 8.
- PIO can be detected in the blood and easily monitored.
In Crinone, progesterone is suspended within a bio-adhesive gel. It is applied vaginally and packaged in a tampon-like applicator. It is sold without the progesterone under the brand name Replens.
Frequently used as a progesterone supplement in IUI and IVF cycles, Crinone gel is very efficient in the uterusso efficient that the progesterone remains in such concentrations in the uterus that Crinone often has minimal impact on serum progesterone levels, meaning that most women apply it just once per day. Additionally, many women find that Crinone is more effective than oral progesterone or suppositories in delaying the premature onset of menstruation.
One minor drawback: Suspension gel can accumulate within the vagina and some women may need to have it removed every few days, and this build-up has been known to lead to vaginal irritation.
Used most frequently in IVF cycles, injectible progesterone (progesterone suspended in an oil) is typically done daily, intramuscularly, often in a one cubic centimeter (cc) dose. It is a relatively inexpensive option.
At the uterine level, progesterone in oil is extremely effective and has developed a reputation among doctors as the best of the best of progesterone supplements, especially in IVF cycles. Serum tests reflect progesterone in oil, allowing levels to be monitored with greater ease. It is
The drawback: Intramuscular injections, already uncomfortable enough, also require a sizeable 20 or 22 gauge needle to cope with the oils high viscosity. And like the suppositories, the injections need either special pharmaceutical compounding or to be ordered through the mail, and it is not uncommon for some women to be allergic to the suspension oil.