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What do you ladies know about elevated levels of progesterone before ER?

September 6 2012 at 10:13 PM
Sara Q  (no login)

 
Hey folks,

I feel like I'm full of questions this week. Please forgive me if it's getting annoying; I'm even starting to annoy myself. wink.gif But to day was a good day, I had a positive outlook and got a lot of work done (Margie!)

Does anyone know anything about elevated progesterone levels before IVF trigger and/or ER? I was attempting to do work tonight but am so dam* tired, probably b/c of my sky-high progesterone, so I was doing some internet surfing about it. Didn't find so much about elevated progesterone at this point in the cycle, but I did find a bunch of stuff about elevated progesterone before trigger and ER.

Here are some of the links:

http://humrep.oxfordjournals.org/content/10/5/1060.abstract

http://jcem.endojournals.org/content/73/4/797.abstract


And links to forums where they are talking about it:

http://www.ivf-infertility.com/phpBB3/viewtopic.php?f=2&t=16149&start=0

http://forums.fertilitycommunity.com/vitro-fertilization-ivf/2020210625-how-important-test-progesterone-er.html


I looked at these because I remember the Coo.per nurses telling me that my P4 had increased the morning before my trigger to 1.14 and then even more the day before ER to 2.2, so I'm assuming it was probably close to 3 at ER. According to these articles, those numbers could significantly reduce implantation potential of seemingly "perfect" embryos.

My old clinic never tested p4 during stimulation or before ER (crazy I know), but apparently one of the signs of premature p4 rise is bleeding through your p4 support before your beta, which I did 2 out of 3 times. Which may provide some sort of explanation for why we implanted 6 seemingly great embryos during those cycles and none took. Maybe it's something more than egg quality and immunology issues? Is that even conceivable?

Has anyone talked to an RE about this issue? What do you know about it?

I know it probably seems like I am driving myself borderline crazy, but I am having a callback with Check in a couple of days (before my beta) and I want to ask good questions so that I may better understand what the heck happened this cycle. I really wish he had been able to weigh in on what was happening, when it was happening. And I just can't shake this feeling that there is something other than poor egg quality going on here...5 8-cells of a 33 year old with no fragmentation transferred and nothing, ever?

If this cycle does not work, we will try one more, but that is it - DH and I talked about it last night. I'm going to be 35 next May, which means that we will have been at this for nearly 4 years. After that it's adoption and DE.

But if we're going to do one more, then I want to shake down every possible lead to solve this riddle.

Any thoughts?

Thanks,
S





 
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  1. I don't see those as concerning levels - Anonymous on Sep 7, 11:23 AM
    1. Thank you so much for your reply - Sara Q on Sep 7, 11:28 AM
     
  2. My 2 cents - b&a72 on Sep 7, 12:56 PM
    1. Thanks b&a. Obviously, I did not read not read these articles all that carefully....;) - Sara Q on Sep 9, 7:04 PM
      1. I hear ya. - b&a72 on Sep 10, 8:46 AM
     
  3. Re: What do you ladies know about elevated levels of progesterone before ER? - Nancy on Sep 8, 7:31 AM
    1. No, no DHEA - Sara Q on Sep 9, 7:09 PM
      1. Re: No, no DHEA - Nancy77 on Sep 10, 5:12 PM
     
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