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POF and treatment protocol

June 27 2016 at 10:15 AM
Mandy  (Login mandy2010)

 
I'm 37 and was diagnosed with POF in December of 2015. In April I was diagnosed with DOR. My FSH was 23 and AMH 0.16, last time it was tested in December, FSH was in the 70's and AMH was 0.03. I started HRT in January to help with the symptoms. I'm currently doing estradiol patches 0.05 mg and progesterone suppositories 100mg for 10 days. Since I've started that the symptoms have improved. I've tried accupunture and herbs and it helped initially, but then my symptoms got worse. I'm currently also taking Maca, ubiquinol, wheatgrass, Royal jelly, prenatal vitamin, evening primrose oil up until I ovulate, Vit. D, L- argine. My Re mentioned trying Femera with a HCG trigger shot. I've also got in touch with a specialist that specializes in treating POF with herbs. My question is should I even try Femera with such a high FSH or should I just try the herbs. The accupunturist said I could take both at the same time, but I thought you couldn't take herbs while trying fertility drugs?

I do have a son conceived naturally almost 6 years ago. We have been trying for 2 years. I got pregnant with him within 2 months and prior to him had a daughter that we lost at 20 weeks conceived naturally as well. I thought I wouldn't have any problems this go around.

 
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Houston
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success mentioned

June 28 2016, 8:10 AM 

I would try the Femara, just so it is low dose, with a trigger shot. I had a very high FSH, tested 2 years 38 prior to conceiving my son, but I suspect it was much much higher based on my changed response to meds in the year prior to getting pregnant. What worked for me was 75 menopur in the morning and a trigger shot (I converted from IVF to IUI b/c I responded with only 1 follicle). I think people with high FSH tend to have trouble maturing eggs and then releasing them (which is why so many cyst), thus, I am a fan of a little help, not too much so egg quality isn't impacted, followed by a trigger.

 
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Mandy
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Thank you

June 29 2016, 7:49 AM 

Houston,
What was your FSH at that time and your AMH? What other treatment modalities did you try or supplements? So confused as to what to do. Thank you.

Mandy

 
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Houston
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Re: Thank you

June 30 2016, 8:13 AM 

2 years prior to conceiving my FSH was 38 and AMH was .28. My response declined drastically since have that test, so I believe my FSH was much higher when I became pregnant. What finally worked for me, but I have no idea if it was just coincidental or not, was a low gluten, low dairy, high protein diet. I was taking a lot of Vitamin D. Way more than recommended, but I forget the specific amount (I'm not recommending this, just saying what I did). I was also taking COQ10, but not religiously.

I was trying a low dose protocol (MDL and estrogen priming) with menopur 75 mg in the morning, with the addition of omnitrope (a growth hormone) at the suggestion of my local doctor. A lot of people with high FSH seem to do better with lower dose protocols as I think it does not harm the sensitive eggs. Some even respond as well. I responded with 1 follicle. I cancelled IVF b/c I was hoping for 2. I refused IUI b/c I was trying to save money for 1 more round. We just did timed intercourse. I don't know if it had to do with the diet, but it and the low dose protocol are what was different than the times before (I may have done low dose 1 other time, I don't recall for sure).

 
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Mandy
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MDL and type of estrogen priming

July 1 2016, 1:39 PM 

What exactly is MDL and what type of estrogen priming did you do? I'm on the estradiol patches, not sure if that's the same thing you tried or not.

 
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Anonymous
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Re: MDL and type of estrogen priming

July 6 2016, 8:20 AM 

mdl is microdose Lupron. It is used to suppress you somewhat, but is used with poor responders instead of long Lupron. It is often used alone, as is estrogen priming (which are the patches you described). They are not often used together, but Dr. Davis at Cornell has some protocols where they are used together (or he did anyway). I used his protocol. Erin on this board posted the exact protocol specifics at one point (maybe on the over 40 board), but I'm not sure how to find the post.

 
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Anonymous
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Re: POF and treatment protocol

June 29 2016, 9:49 AM 

MINI IVF..

 
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