William Allison an English Turf writer and bloodstock expert used mathematical and scientific formulae in 1891 and 1892 to build The Castleton Foundation Dynasty at the Tattersalls Sales in England. The mares developed directly produced the most influential racers sires of 20th century America including Peter Pan and his son Pennant, Sweep. Broomstick and Black Toney.
James Keene commissioned William Allison to acquire key mares from Castleton Dynasty for use in America. James Keene then bred Sysonby and Colin among other stars. Math science breeding goes back to the 1890s and it appears much earlier as well.