The particular advantage of fluconazole is that it gets everywhere and penetrates skin as well as coming out in secretions and excretions. The brief "flash" of the antibiotic in urine, semen, pre-ejaculatory fluid and vaginal secretions will tend to clear superficial Candida, but its persistence in the skin itself makes that inhospitable for the organism to persist in the surface skin and mucous membranes.
Once weekly administration is thus adequate for this degree of Candidiasis, though more frequent administration - on prescription - is used for more serious (and potentially life-threatening) infestations in immunocompromised (particularly AIDS) persons.
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