they study looked at women who had been taking high dose NSAIDS for a long period of time to relieve arthritis pain. Once they drugs were stopped the effect when away. Actually NSAIDs have recently been shown to benefit preparation of the uterine lining for implantation in IVF cycle... this again, is SHORT TERM USE!
NSAID primes uterus for IVF-embryo transfer
Source: Fertility and Sterility 2004; 82: 816-20
Treatment with a non-steroidal inflammatory drug shortly before embryo transfer may have a positive effect on the outcome of IVF.
A non-steroidal anti-inflammatory drug (NSAID) often used to treat arthritis and dysmenorrhea appears to be "very effective" at priming the uterus for embryo implantation during IVF-embryo transfer (ET), say Korean researchers.
Hwa Sook Moon (Good Moon-Hwa Hospital, Busan) and colleagues theorized that treatment with the NSAID B-cyclodextrin piroxicam 1-2 hours before embryo transfer would prime the uterus for implantation and thereby improve the outcome of IVF-ET.
To test this hypothesis, they conducted a double-blind, randomized, placebo-controlled trial of 188 fresh and 78 frozen-thawed IVF-ET cycles performed between March 1998 and February 2002.
The team found that, overall, priming the uterus with piroxicam significantly increased implantation and pregnancy rates in both fresh and frozen-thawed cycles, compared with placebo.
Further analysis of the fresh cycle data revealed that these benefits reached statistical significance in women younger than 40 years old and in couples with tubal, male, or endometriosis-factor infertility, but not in older women or in those with unexplained infertility.
"These results suggest that piroxicam treatment before ET is very effective in the priming of the uterus suitable for embryo implantation," conclude the authors.
Pat - AKA - Satie37