Nancy, thanks for starting this thread. I think it could be really useful for us. Sorry for how long it's going to be, but you never know what might be useful to someone.
I am 36, about to turn 37 in a few days. DH is 43. We've been married 5 years. After we were married one year, we started TTC #1. It took 4 mos, we had an easy pregnancy, and have one DD, now 2yrs9mos.
When she was 18 months we started TTC #2, when I was 35. That was Nov. 2004. I worried that we might have to deal with a m/c, since they are so common, so we started a little earlier than would have been ideal for me. I got pregnant the first month. In January 2005, at the 7.5 wk checkup, they discovered 3 empty sacs (I think they were empty --maybe there was a yolk sac in 2 of them). Because natural triplets are so unusual, they gave it another week. No fetal poles, so I had a D&C a few days later. I got my period 5 weeks later.
After 3 mos started trying again, expecting to conceive quickly, and then didn't get pregnant until 5 mos later. In October 2005 I had a chemical pregnancy, m/c #2 at 5 wks.
My OB said to go see the RE and I got an appointment the next month. On the day of my appt, I was 12 dpo, and had a faint line on FRER. That ended as another chemical pregnacy - my third m.c.
In Nov. 2005, right after the 3rd m/c, I got my first FSH reading of 15.2. Subsequent readings were 10, 8, and 10, so I feel that the first one was a little high because of the m/c. I got the whole recurrent m/c work-up done (I thought); I am hetero for one copy of the MTHFR gene (the one that's not so bad, that about 60% of the population has). I'm on 4000 mg folic acid, and B6 and B12 and baby aspirin for that. I tested postive for just one of the APA's (did the full panel with that lab out in Calif, can't remember it's name) and my doctor thought that was not of any concern. I thought the only thing I didn't get tested for was NK Killer cells, which he doesn't believe in.
I then had a consult with Dr. Check. He thought the only thing i needed was progesterone. Said maybe LIT might help, but he didn't think so. Thought IUI's were a waste of time for me, and I shouldn't use lots of drugs because that creates a bad uterine environment in people with high FSH. He recommended naturally with prog, or natural IVF if I wanted to get it done fast.
Well, I did one IUI cycle with my local RE, it failed, then got pregnant on a natural cycle 2 mos later, in Feb. 2006. (So, it has taken me 4 mos, 1 mos, 5 mos, 1 mos, 4 mos to get pregnant). My betas doubled nicely up to 22 dpo, and then didn't rise appropriately at 27 dpo, and no fetal pole at the 7wk u/s, so had a D&C that day, which was last week. I was really hopeful about this one, as it seeme different from the others, so I am finding it really hard to deal with. I know I'm lucky to have my DD, but it is still hard.
I'm moving on to IVF with PGD. I'm going to do one cycle with my local RE. He is expensive, and he is going to do a high-stim cycle, which Check would disagree with. But m/c are just such a waste of time. You have to wait that whole time that you are pregnant, and then 2 more cycles after that if you have a D&C. I'm sure Check could get me pregnant with a natural IVF, but I don't see why I wouldn't miscarry, as I now believe most of my eggs are bad. So what I want to do is see if I can get lots of eggs and test them before implanting them. May not get lots of eggs because of the high FSH, but I want to try.
THINGS OF NOTE: I met with the PGD specialist yesterday, and found that I had not had karyotype testing for translocation abnormalities. In PGD, they test for 1) aneuploidy (extra or missing chromosomes, leading to Down's, Trisomy 13, etc.) and 2) translocations (some chromosome matter is in the wrong place in the parent). My RE thinks my high FSH means I have bad/old eggs, leading to aneuploidy. You only test the embryos for translocations if one of the parents has a translocation. The parent can have a balanced translocation, but it can easily get passed to the child as an unbalanced translocation, leading to m/c. I can't believe this wasn't tested before, as part of the recurrent m/c work-up. But it wasn't. I'm still waiting for my results.
Also, the PGD specialist believes there is no correlation between high FSH and m/c. And given there seem to be so few of us, maybe he's right. Maybe we just have high FSH, and really bad luck. He said there was some huge study going on right now looking at that, and we may have an answer in 6 mos.
I am going to do LIT before I cycle again. If any of you are interested, you should consult with Dr. Check if you are reasonably close to him (I am about 3 hours away), and he may give you ideas on how to do it. I don't even really know what it is, but it has something to do with immune issues and he thinks it might help (maybe he would be more sure now that I have had another m/c even with prog. support), so why not.