My DD Amanda has been on methotrexate (mtx for short around here - just easier to type!) since 1999. She started out on pills but they upset her stomach so we moved to injections. She was initiallly on 5 mg and went up to 12.5 mg. She is still on it and has some "day after" nausea but she manages it. Right now, it isn't doing much for her and it may be changed. But, when she was initially on it, she got alot of relief from it. I know it seems like a scary drug but they have a long history of treating kids with it for arthritis and that gives me some comfort. According to our rheumatologist, it's been used for over 30 yrs and they know alot about it. Make sure Ayla takes 1 mg folic acid daily and that'll combat the side effects of nausea. She'll require monthly blood work to monitor her liver functions. This too sounds scary but liver enzymes can go wonky before there's any actual damage to the liver.
I hope that gives you some info. Let me know if there's anything else you need to know.
Michelle
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