Thank you so much for responding! It gives me so much hope to hear how your daughter has progressed. The information on the 2 in 1 Embryl is priceless to me - I am going to discuss this with her Rheumatologist. What a good idea to do the shots at night. We did the first one yesterday evening and it was fairly traumatic for her so I am going to discuss your approach with my husband (he is giving the shots as I am breastfeeding and shouldn't handle the methatrexate). THANK YOU!!!