Poor guy. He must feel just miserable. I hope things start looking up for him promptly.
The paper that Will pointed out a while ago
http://bloodjournal.hematologylibrary.org/cgi/content/abstract/blood-2009-03-212449v1) has been on my mind. (It's about HCLers for whom cladribine doesn't work very well.) The second purine treatment can be a big success for some people though, and I hope Steve is one of those people.
-w.