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lithium and haloperidol incompatibility

May 6 2007 at 3:28 PM

The American Journal of Psychiatry
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Am J Psychiatry 1981; 138:818-821
Copyright © 1981 by American Psychiatric Association


New data on lithium and haloperidol incompatibility

G Spring and M Frankel

The authors describe a case of combined lithium and haloperidol toxicity characterized by hyperpyrexia, severe rigidity, mutism, and development of irreversible tardive dyskinesia. This case is similar to four other cases described in the literature and to the neuroleptic malignant syndrome. The authors postulate that two types of combined lithium-neuroleptic toxicity occur: a neuroleptic malignant extrapyramidal syndrome and a lithium toxicity that occurs in combination with phenothiazines, primarily thioridazine. Possible mechanisms and preventive measures are discussed.

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M. P. Freeman and A. L. Stoll
Mood Stabilizer Combinations: A Review of Safety and Efficacy
Am J Psychiatry, January 1, 1998; 155(1): 12 - 21.
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