Antidepressant Half Life Information
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Sep-01 |
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| drug |
generic name |
company |
type |
max mg/day |
Half life, hrs |
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| Anafranil |
clomipramine |
Novartis |
TCAD |
250 |
21(19-37) |
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| Asendis |
amoxapine |
Wyeth |
TCAD |
300 |
no info |
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| Cipramil |
|
Lundbeck |
SSRI |
60 |
36 (28 - 42) |
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Elderly patients may metabolise more slowly and need lower dose |
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| Edronax |
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Pharmacia |
SNRI |
12 |
8 |
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| Efexor |
venlafaxine |
Wyeth |
SSNRI |
375 |
5 (5 to 11) |
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| " XL |
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Wyeth |
SSNRI |
225 |
20 to 22 |
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| Faverin |
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Solvay |
SSRI |
300 |
21 |
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| Lentizol |
amitriptyline hyd. |
Pfizer |
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200 |
15 (10 - 28) |
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Nortriptyline, the most important metabolite, has a half-life of 36 hours (18-60 hours). |
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It has a polymorphically controlled metabolism (debrisoquine metabolism). In subjects |
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with a slow metabolism (in Switzerland about 9% of the population) high therapeutic |
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doses can lead to toxic plasma levels very quickly. |
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| Lustral, |
sertraline |
Pfizer |
SSRI |
200 |
26 (22 to 33) |
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| Prothiaden |
dothiepin hyd. |
Knoll |
TCAD |
150 |
19 to 33 |
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| Prozac |
fluoxetine |
Dista |
SSRI |
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7 to 9 DAYS |
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Approx. 7% of people have difficulty metabolising fluoxetine and it then increases rapidly |
| Seroxat |
paroxetine |
GSK |
SSRI |
50 |
21 to 26 |
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| Sinequan |
doxepin |
Pfizer |
TCAD |
100x3 p.d. |
28 to 52 |
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| Surmontil |
trimipramine |
Futuna |
TCAD |
300 |
24 |
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| Tofranil |
imipramine |
Novartis |
TCAD |
200 |
19 |
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Elderly shown to have slower metabolism giving half life of 28 hours. |
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Young me shown to have higher metabolism giving half life of 16 hours. |
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| Triptafen |
phenothiazine |
Goldshield |
TCAD |
4 tabs daily |
30 |
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| Zispin |
mirtazapine |
Organon |
N&S enhancer |
45 |
20 to 40 |
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http://www.clinical-depression.co.uk/half_life.htm
