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study confirms association of quetiapine treatment and impairment of glucose homeostasis

February 17 2011 at 9:08 AM

Response to 'Seroquel I: Introduction to an "atypical" '

Prog Neuropsychopharmacol Biol Psychiatry. 2011 Feb 1. [Epub ahead of print]

A prospective study of glucose homeostasis in quetiapine-treated schizophrenic patients by using the intravenous glucose tolerance test.

Chen CH, Lin TY, Chen TT, Chen VC, Lin NC, Shao WC, Lu ML.

Department of Psychiatry, School of Medicine, College of Medicine, Taipei Medical University, Taipei, Taiwan; Department of Psychiatry, Taipei Medical University-Wan Fang Hospital, Taipei, Taiwan.


Increasing attention has been paid recently to the potential diabetogenic effect of second-generation antipsychotics (SGAs). The objective of this prospective study was to evaluate the effects of quetiapine treatment on pancreatic beta-cell function in SGA-naïve schizophrenic patients. Seventeen schizophrenic subjects completed an eight-week trial. The metabolic parameters were assessed at weeks 0, 2, 4, and 8. We measured glucose homeostasis with the intravenous glucose tolerance test. After the eight-week treatment, body weight and body mass index showed to be significantly increased compared to those at baseline. No significant changes were found in serum levels of fasting glucose, insulin, total cholesterol, and high-density lipoprotein. Insulin resistance and insulin secretion were significantly increased. Incidences of clinically significant weight gain and treatment-emergent metabolic syndrome were 11.8% and 11.8%, respectively. This study result confirms the association of quetiapine treatment and impairment of glucose homeostasis in schizophrenic patients.

Copyright © 2011. Published by Elsevier Inc.

PMID: 21291941 [PubMed - as supplied by publisher]

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