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trial rigged as medication withdrawan to sawp to placebo arm !

May 4 2011 at 9:02 AM

Response to Long-term use of bipolar drug questioned .... ABILIFY

We describe four issues that limit the interpretation of that trial as supporting the use of aripiprazole for bipolar maintenance: (1) insufficient duration to demonstrate maintenance efficacy; (2) limited generalizability due to its enriched sample; (3) possible conflation of iatrogenic adverse effects of abrupt medication discontinuation with beneficial effects of treatment; and (4) a low overall completion rate. Our citation search protocol yielded 80 publications that cited the Keck et al. trial in discussing the use of aripiprazole for bipolar maintenance. Of these, only 24 (30%) mentioned adverse events reported and four (5%) mentioned study limitations.

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  1. rapid withdrawal made placebo group "artificially prone to relapse" - Anonymous on May 4, 2011, 9:06 AM
    1. Thats a situation that probably runs through - admin on May 5, 2011, 11:42 AM

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