Click Here For
WiredPatrol Site
"You Are a Child of the Universe, No Less than the Trees or the Stars"
 RETURN TO MESSAGES INDEX  

trial rigged as medication withdrawan to sawp to placebo arm !

May 4 2011 at 9:02 AM
Anonymous 


Response to Long-term use of bipolar drug questioned .... ABILIFY

We describe four issues that limit the interpretation of that trial as supporting the use of aripiprazole for bipolar maintenance: (1) insufficient duration to demonstrate maintenance efficacy; (2) limited generalizability due to its enriched sample; (3) possible conflation of iatrogenic adverse effects of abrupt medication discontinuation with beneficial effects of treatment; and (4) a low overall completion rate. Our citation search protocol yielded 80 publications that cited the Keck et al. trial in discussing the use of aripiprazole for bipolar maintenance. Of these, only 24 (30%) mentioned adverse events reported and four (5%) mentioned study limitations.

 
 Respond to this message   
Responses

  1. rapid withdrawal made placebo group "artificially prone to relapse" - Anonymous on May 4, 9:06 AM
    1. Thats a situation that probably runs through - admin on May 5, 11:42 AM
     


Visit RxISK ORG from Data Based Medicine
'the first free website (not sponsored by big pharma or advertising) for patients
and their doctors to research, and more importantly, easily report drug side effects'.