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Charity funding UK trial of psychiatric drug LITHIUM in motor neurone disease

November 5 2008 at 12:57 PM
Anonymous 

The UKs Motor Neurone Disease (MND) Association will fund a clinical trial investigating whether the standard mood stabiliser lithium could be an effective treatment for MND.

 

>http://www.pharmatimes.com/ClinicalNews/article.aspx?id=14669



Up to 220 patients from 10 MND Care Centres across England will be recruited for the £1 million trial, which the charity hopes will start in the first half of 2009. It will be run through the National Institute for Health Researchs Dementias and Neurodegenerative Diseases Research Network (DeNDRoN), which provides a National Health Service infrastructure to support research alongside clinical practice.

The MND Association has been developing a network of care centres throughout England, Wales and Northern Ireland since 1990. There are currently 17 MND Care Centres in total. Some 5,000 people are living with MND in the UK while 100,000 people have the disease worldwide.

This is the first time the MND Association has been in a position to fund its own clinical study, it noted. Around £400,000 of the £1 million investment will come from the association while DeNDRoN is funding the service support costs of about £540,000.

At the moment, the charity noted, lithium is occasionally prescribed to people with MND to treat accompanying or pre-existing disorders. However, online MD communities are now aware of the possible effects of lithium in slowing the disease and within some patient-group forums, members with the disease are asking how they can obtain lithium without prescription.

Italian study

As the MND Association noted, laboratory studies have shown that lithium can have a protective effect on motor neurones and the drug has produced positive effects in the mouse model of MND. Moreover, in February Italian researchers published the results of a small clinical trial suggesting that lithium could slow the progression of MND.

The Italian team led by Francesco Fornai from the Department of Human Morphology and Applied Biology at the University of Pisa conducted a parallel-group, randomised study of lithium in amyotrophic lateral sclerosis (ALS), which is the most common sub-type of MND. Out of 44 adults with ALS, 16 were randomised to the approved treatment riluzole (Rilutek) plus lithium, and the remainder to riluzole alone.

According to the results published in the US journal Proceedings of the National Academy of Sciences, after 15 months no deaths had occurred in the 16 patients treated with riluzole plus lithium, whereas 29% of the riluzole-only group had died. Disease-related disability was also markedly less pronounced in the riluzole-lithium patients.

Based on these promising but inconclusive findings, a North American consortium including the ALS Association in the US, the ALS Society of Canada and the US National Institutes of Health/National Institute of Neurological Diseases and Stroke announced in September that it would fund a double-blind, placebo-controlled trial with 84 early-stage ALS patients at sites in the US and Canada.

These patients will be randomised to either lithium or placebo. Once the 84th participant has been enrolled, a decision will be taken on whether to expand the trial to 250 patients. The UK study will run in parallel to this trial. It is necessary to conduct both of these trials due to the requirement to repeat experiments to ensure that the results obtained from both trials are correct, the MND Association commented. The results found will also be comparable and therefore will provide us with more data, quicker.

The MND Association said the results of the Italian trial were encouraging but should be treated with extreme caution as the study had significant weaknesses. Moreover, noted the associations director of research and development, Dr Brian Dickie, lithium can affect several chemical processes in the body, with the potential to cause side-effects. It is therefore essential that all patients involved in this trial are very carefully monitored.

Nonetheless, commented Professor Nigel Leigh, the director of the Kings MND Centre at Kings College London who will spearhead the UK trial, the Italian outcomes are too dramatic to ignore We need to know the truth about lithium and we have a robust trial which will deliver real answer.

The UK study will be a randomised, double-blind, placebo-controlled trial in which patients will take lithium once a day for 18 months. The inclusion criteria will include: age over 18 years; a diagnosis of ALS according to World Federation of Neurology criteria; between six months and three years since the onset of symptoms; on riluzole therapy for at least four weeks; respiratory function of forced vital capacity greater than 60% of predicted; and able to understand fully study information and provide informed consent.

In the US, a small but significant number of people with MND are managing to obtain lithium from their doctors, but they are taking markedly different doses and are not being closely monitored under trial conditions, Dickie pointed out. At the moment the answer to whether lithium is having any positive impact on the disease is getting lost in the hype and noise.
By Peter Mansell


 
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Anonymous

Charity will help test cheap psychiatric drug for brain condition ...

November 5 2008, 12:58 PM 

Charity will help test cheap drug for brain condition ... 4 Nov 2008 ... Northampton Chronicle and Echo ... Northampton town centre, has announced it will recruit patients to see if lithium can cure the condition. ...
www.northamptonchron.co.uk/news/Charity-will-help-test-cheap.4655657.jp - >Similar pages - http://www.northamptonchron.co.uk/news/Charity-will-help-test-cheap.4655657.jp')})" www.google.co.uk/search?hl=en&safe=off&rlz=1T4GZEZ_en-GBGB262GB262&q=Northampton+Chronicle+%26+Echo+lithium&btnG=Search&meta=#">Note this

 
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Anonymous

just wait until pharma whore Marjorie Wallace runs trials via SANE !!

November 5 2008, 1:00 PM 

1182122438_MFIA-marjorie_wallace.jpg

 
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Anonymous

sorry m'lady - pharma whore Countess Skarbeck

November 5 2008, 1:03 PM 

portrait of Marjorie Wallace (Countess Skarbeck)

 

>http://www.npg.org.uk/live/search/portrait.asp?LinkID=mp86200&rNo=0&role=sit

NPG P1128(13)   NPG P1128(13)
Marjorie Wallace (Countess Skarbeck)
by Julia Fullerton-Batten
C-type colour print, 22 March 2006
Transferred from Julia Fullerton-Batten commissioned and purchased through Deloitte Acquisition Fund for Photographs Collection and transferred, 2006-11-23
>Primary Collection

www.npg.org.uk/live/search/getPrint.asp?npgNo=NPG+P1128(13)&title=Marjorie+Wallace+%28Countess+Skarbeck%29&option=0>Getting a print of this image
www.npg.org.uk/live/search/license.asp?npgNo=NPG+P1128(13)&title=Marjorie+Wallace+%28Countess+Skarbeck%29>Licensing this image
www.npg.org.uk/live/search/useOnWeb.asp?npgNo=NPG+P1128(13)&title=Marjorie+Wallace+%28Countess+Skarbeck%29">Using this image on your website

Sitter
Marjorie Wallace (Countess Skarbeck) (1943-), Writer and journalist; founder of SANE mental health charity. Sitter in 1 portrait.

Artist
Julia Fullerton-Batten (1970-). Artist of 16 portraits.

Portrait Set
Figures in the Health Sector: colour photographs by Julia Fullerton-Batten, 2006

Subject/Theme
Making music


 
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Anonymous

Countess Skarbek ordered a piano placed out on the lawn ... so the young Chopin could play

November 6 2008, 10:22 PM 

Countess Skarbek ordered a piano placed out on the lawn under the beech trees so the young Chopin could play to her household in the evenings. We also know that in Zelazowa Wola he listened to wandering gypsy bands playing mazurkas and other country dances that he was to immortalize in his compositions.

 

 

A VILLAGE ECHOS CHOPIN'S THEMES

  http://query.nytimes.com/gst/fullpage.html?res=9806EFDD1F39F936A25752C1A967948260&sec=travel&spon=&pagewanted=all>  

PAUL LEWIS is a correspondent in Paris for The New York Times. By PAUL LEWIS

T he first sounds the infant son of Nicholas and Justina Chopin heard when he entered the world on Feb. 22, 1810, were the lively peasant tunes of the fiddlers and pipers of Zelazowa Wola, a melodiously named village not far from Warsaw. By a happy coincidence, so the story goes, the village musicians were passing his mother's bedroom on their way to festivities at the nearby manor house of Countess Skarbek.

Today, a hugh white urn, filled with flowers in summer and with grasses and evergreen sprigs during the long Polish winter, stands in the bedroom alcove where Frederic Chopin was born. From concealed loudspeakers, the piano music of Poland's greatest composer, so heavily spiced with the rhythms of the countryside, drifts constantly through the small cottage on the old Skarbek estate and out over the gardens and woods beyond.

Chopin's birthplace, to which he often returned as a guest of the Countess during his adolescence, is preserved as a museum, a concert center and a place of pilgrimage for musicians and music lovers from all over the world. But in Poland's present crisis the cottage and the copious gardens that now surround it take on a special significance.

In a country worn threadbare by economic hardship, they are a haven of tranquillity and beauty. But they are also an eloquent reminder of Poland's long and tragic struggle to defend itself against the acquisitive advances of its neighbors, a struggle that seems far from over today.

Driving out to Zelazowa Wola one warm Sunday this fall, I found it chilling to recall how little the country's problems had changed over the centuries. I had left behind a Warsaw awash with rumours of an imminent Soviet invasion, a concern that would not have surprised Chopin. By the time Chopin was five years old, Czar Alexander I of Russia had formally declared himself King of Poland, having already grabbed much of the country in the company of Austria and Prussia.

On entering the cottage for the first time, it was moving beyond words to be greeted, through an extraordinary fluke, by the thunderous chords and angry cascade of semiquavers that mark the opening of the ''Revolutionary'' etude in C Minor. Chopin was an ardent nationalist and this work expresses the rage and frustration he felt after the brutal Russian suppression of the 1830-31 Polish uprising. ''Oh God, you exist and yet you don't avenge,'' he wrote from Stuttgart at the time. ''Have you not had your fill of Moscow's crimes?''

Like everything else in Poland these days, getting out to Zelazowa Wola is not easy, but dollars help. Public transportation does not exist, so the best idea is to take a taxi, offering the driver dollars or some other Western currency that he can spend in Poland's well-stocked foreign-currency shops. After initially demanding $25 for the half-day trip, my driver settled for $15.

Zelazola Wola is only about 40 miles from Warsaw, but the one-hour drive is a journey back in time. Soon the shabby blocks of workers' apartments give way to narrow, bumpy country roads running past rows of neat peasants' cottages, many of them beautifully carved wooden buildings that date from the 19th century.

In October, during what the Poles call their ''golden autumn,'' their gardens are a mass of roses and marigolds. Conical hayricks dot the fields like oversized molehills, while long, thin horse-drawn carts that have not changed in hundreds of years roll slowly along, loaded with potatoes, beets and cabbages.

The village is on the Masovian plains, an area known as the ''Heart of Poland.'' The landscape is absolutely flat but crisscrossed by meandering streams lined with willow trees. More than one biographer has heard some echo of the delicate strength of these Masovian willows in Chopin's music. And Chopin himself wrote, ''I am a true Masovian.''

The single-story cottage, a long, ivy-covered building of six rooms, is surrounded by gardens that dip down in terraces to a little river. In homage to the composer, botanical gardens all over the world sent more than 10,000 trees and shrubs to be planted when the Polish Government bought the cottage and turned it into a museum in 1930.

In October the path that winds up to the cottage door from the entrance gate is still bordered by banks of chrysanthemums, roses and white irises. (Admission is 20 zloties, less than $1.) Donkeys graze on the lawns beyond, while overhead hugh beech trees, turning gold now, offer shade from the suprising warmth of the midday sun.

Chopin led an exile's life in troubled times, dying of consumption in Paris at the age of 39. His music, of course, is preserved along with many letters. And his heart was returned to Poland for burial in Warsaw's Holy Cross Church. But few other mementos of his life have survived. Although the cottage is furnished as it might have been in Chopin's day, it contains only a handful of items the composer would recognize.

On a sunny day, the cottage seems airy and bright, with white walls and designs painted in delicate colors on the ceiling beams. In winter the rooms are heated by blue-tiled woodstoves. The unpretentious furniture includes an old mahogany grandfather clock, a dining room set of polished black wood, silk-covered settees and 19th-century prints of Warsaw.

The big black Steinway grand tucked into a corner of the music room contrasts with a 19th-century ''upright grand'' that looks like a harp standing on a keyboard in another room. The difference between the full tone of a modern piano and the tinkling noise of the kind of instrument Chopin used makes one wonder whether he would even recognize his own music today.

Some framed musical manuscripts together with several decorated poems, which Chopin as a small boy presented to his parents on their birthdays, provide a direct link with the composer.

So do some of the pictures - not the reproductions of the portraits by Delacroix and Scheffer but less well-known pictures like the two sketches of him at 19 by Princess Radziwill, drawn when he was staying at her family's castle.

''She's young, 17, pretty and it's a delight to guide her fingers on the keys,'' he wrote of the Princess whom he helped with piano lessons. In return she recorded his delicate birdlike profile while he sat at the piano. The other, full-face sketch, in color, noted dark patches under his eyes, a hint of the disease that was to claim him so young.

The portraits of Chopin's parents in the dining room suggest that the composer's powerful nose came from his schoolmaster father, while his sensuous mouth seems an inheritance from his mother, the daughter of an impoverished aristocrat who worked as Countess Skarbek's housekeeper. Chopin's father was a tutor to the Countess's sons.

Countess Skarbek ordered a piano placed out on the lawn under the beech trees so the young Chopin could play to her household in the evenings. We also know that in Zelazowa Wola he listened to wandering gypsy bands playing mazurkas and other country dances that he was to immortalize in his compositions.

So it is fitting that on Sundays in summer, those who make the journey to the cottage should be invited to listen to some of Poland's finest pianists perform Chopin's works out on the terrace under the beech trees, where the master once played. It is a perfect end to a moving pilgrimage.

The Chopin museum is open the year round from 9 A.M. to 4:30 P.M. on weekdays, 9 to 2 on Saturday; from May to September it is open on Sunday from 9 to 4:30. The recitals are given on Sunday from May to September, one at 11 A.M. and another at 3 P.M.


 
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