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Increase In Long-term Antidepressant Drug Use, UK Study Reveals

October 29 2009 at 9:47 AM
Anonymous 

Increase In Long-term Antidepressant Drug Use, UK Study Reveals

ScienceDaily (Oct. 23, 2009) A dramatic rise in antidepressant prescriptions issued by GPs has been caused by a year on year increase in the number of people taking antidepressant drugs on a long-term basis, according to researchers from the University of Southampton.


   

In a paper, published in the printed edition of British Medical Journal (BMJ), scientists found that despite a drop in the number of new patients diagnosed with depression over 11 years, the number of prescriptions doubled.

"We estimate that more than 2 million people are now taking antidepressants long-term over several years, in particular women aged between 18 and 30," comments Tony Kendrick, a professor in Primary Medical Care of the University's School of Medicine, who led the study.

The number of prescriptions issued per patient rose from 2.8 in 1993 to 5.6 in 2004.

Prescription Pricing Authority data shows that more than 30 million prescriptions for SSRIs (selective serotonin reuptake inhibitors) such as Prozac and Seroxat, are now issued per year, twice as many as the early 1990s. Researchers at the University of Southampton found 90 per cent of people diagnosed with depression are now taking SSRIs either continuously or as repeated courses over several years.

Professor Kendrick adds: "Our previous research found that although these drugs are said not to be addictive, many patients found it difficult to come off them, due to withdrawal symptoms including anxiety. Many wanted more help from their GP to come off the drugs. We don't know how many really need them and whether long-term use is harmful. This has similarities to the situation with Valium in the past."

The research team analysed all new cases of depression between 1993 and 2005 from anonymous computerised general practice records covering 170 GP surgeries and 1.7 million registered patients.



 
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Anonymous

SSRI rise down to serial use

October 29 2009, 9:51 AM 

BBC NEWS
Prozac rise 'down to serial use'

An increase in prescriptions for anti-depressants is due to doctors giving drugs to the same people for longer periods of time, a study has found.

Researchers looked at UK prescriptions over nearly a decade, and found that the number of new patients diagnosed with depression had fallen.

However, the number of prescriptions doubled over the same period of time.

Writing in the BMJ, researchers called for new guidance on long-term prescribing and regular reviews.

The Southampton University team looked at all new cases of depression between 1993 and 2005 from the anonymous records of UK general practitioners.

Incidence in young women aged between 18 and 30 did rise but, overall, the number of new cases fell by almost 25%.

Nevertheless, anti-depressant prescribing doubled during the period, with the number of prescriptions issued per patient rising from 2.8 in 1993 to 5.6 in 2004.

The increase in anti-depressant prescribing has frequently made headlines amid concerns about both cost and efficacy.

Official data shows these prescriptions rose 36% between 2000 and 2005. Selective Serotonin Reuptake Inhibitors (SSRIs), a family of drugs which includes Seroxat and Prozac, accounted for half of all prescriptions and costs.

A major review of these drugs, published last year, suggested they had only marginal effect but this has been vigorously rejected by the manufacturers.

Easy to prescribe

Rather than there being a lower threshold for treatment - as is often suggested - "the dramatic changes in antidepressant prescribing volumes between 1993 and 2005 seem to be largely because more patients are on long-term medication and this group consumes the most drugs," said lead author Professor Tony Kendrick.

"In order to better understand the rise in antidepressant prescribing, research needs to focus on chronic prescribing and policy needs to focus on encouraging appropriate high quality monitoring and review of those patients who become established on long-term prescriptions."

Dr Tim Kendall, of the National Collaborating Centre for Mental Health, said the study's findings suggested doctors were prescribing drugs to people who no longer needed them.

"Unfortunately, the SSRI antidepressants have a withdrawal syndrome and many people find it hard to stop them; so whether they are depressed in the first place or just unhappy, they end up needing them for longer than is probably good for them.

"Depression is a big problem in the UK and talking treatments, such as cognitive behavioural therapy or interpersonal therapy can be very effective indeed for many people; they also don't have a withdrawal syndrome.

"We don't have to depend so much on antidepressants which are hard to stop and easy to prescribe."

Marjorie Wallace, SANE's chief executive, said: "It is important that any drug used to treat a person's mood or mental state should be taken particularly seriously and kept under constant review.

"And those being prescribed such medications should be given more information about possible side effects.

"For mild to moderate depression, talking therapy is recommended as first-line treatment, with anti-depressants used preferably in combination," she said.

"It is a pity that with so many people having to wait for such therapies, still in some places an anti-depressant is the only thing a doctor is able to prescribe."
Story from BBC NEWS:
http://news.bbc.co.uk/go/pr/fr/-/2/h...th/8319345.stm

Published: 2009/10/21 23:02:17 GMT


 
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Anonymous

Bleak Britain: Anti-depressant prescriptions soar even though illness declines

October 29 2009, 9:52 AM 

Bleak Britain: Anti-depressant prescriptions soar even though illness declines
http://www.dailymail.co.uk/health/ar...-declines.html

By Jenny Hope
Last updated at 2:37 AM on 24th October 2009

Comments (12)
Add to My Stories
Prescriptions for anti-depressants have soared despite fewer patients being diagnosed with depression, research shows.

It reveals the number of prescriptions issued by GPs for drugs including Prozac and Seroxat has more than doubled over the past 11 years.

And it warns the dramatic rise is largely down to more than two million patients taking antidepressants for years at a time - many of them young women.


Young women were more likely to take anti-depressants long term, according to the study (posed by model)

Prescriptions for anti- depressants have soared despite fewer patients being diagnosed with depression, research shows.

It reveals the number of prescriptions issued by GPs for drugs including Prozac and Seroxat has more than doubled over the past 11 years.

And it warns the dramatic rise is largely down to more than two million patients taking antidepressants for years at a time - many of them young women.

The study, by Southampton University and published in the British Medical Journal, analysed all new cases of depression between 1993 and 2004 from anonymous computerised general practice records.


The database covers 170 GP surgeries and around 1.7million registered patients.

It found the number of prescriptions issued for antidepressants per patient rose from 2.8 in 1993 to 5.6 in 2004.

Data from the Prescription Pricing Authority also found more than 30million prescriptions for SSRIs (selective serotonin reuptake inhibitors), such as Prozac and Seroxat, are issued each year - twice as many as the early 1990s.

The study also found 90 per cent of those diagnosed with depression now take SSRIs either continuously or as repeated courses over several years.

Researchers said they feared the rise could result in addiction problems like those affecting users of the anti-anxiety drug Valium 30 years ago.


Prozac: Widely prescribed

And they claimed many patients, particularly women, were taking the drugs over a long period rather than to alleviate symptoms in the short-term.

Many subsequently had trouble getting the help they needed to treat their addiction, they added.

Professor Kendrick, who led the study, said: 'We estimate more than two million people are taking antidepressants long-term, in particular women aged between 18 and 30.

'Our previous research found although these drugs are said not to be addictive, many patients found it difficult to come off them, due to withdrawal symptoms including anxiety.

'Many wanted more help from their GP to come off the drugs. We don't know how many really need them and whether long term use is harmful. This has similarities to the situation with Valium in the past.'

He said the UK was among several western European countries which had seen a substantial rise in antidepressant prescribing in the past 20 years.

'Lower thresholds for diagnosis or treatment, or changes in illness or behaviour do not seem to be responsible for this rise,' he said.

'The rise in antidepressant use is mainly explained by changes in the proportion of patients receiving long-term treatment.'

Previous studies have shown psychological therapies can be as effective as drugs in tackling mental health problems, and may work better in the long term.

NHS guidelines recommend this kind of treatment, including cognitive behavioural therapy, often in preference to drugs.

Research by five mental health charities found depressed patients were having wait for six to 18 months to get an appointment with an NHS counsellor - with many being forced to go private.

Many GPs admit prescribing antidepressant medications to patients because they can't get access to talking therapies.





 
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Anonymous

SSRI / SNRI totals (all brands) 1998 - 2008 UK national statistics

October 29 2009, 9:56 AM 

1998 to 2008 the total median increase in SSRI / SNRIs prescriptions was over 1.61 Million.


****
Data collection reference:
Department of Health; NHS; Prescription Cost Analysis (PCA) - England.
1998 to 2007:
http://www.dh.gov.uk/en/Publications...are/DH_4086488
2008:
http://www.ic.nhs.uk/webfiles/public...PCA%202008.pdf
P1 Tuesday


http://www.tuesday1st.blogspot.com/

 

3492594974_74196089f1_o.jpg


 
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Anonymous

are all SSRI rising or are some actually in decline?

October 29 2009, 9:59 AM 

1998 total prescriptions for the SSRI / SNRI drug class were 8,27 Million, in 2008 total prescriptions for just one of the drug class, Citalopram / Cipramil, were over 8.99 Million.


****
Data collection reference:
Department of Health; NHS; Prescription Cost Analysis (PCA) - England.
1998 to 2007:
http://www.dh.gov.uk/en/Publications...are/DH_4086488
2008:
http://www.ic.nhs.uk/webfiles/public...PCA%202008.pdf
P2 Tuesday

 

http://www.tuesday1st.blogspot.com/

3492596460_045aef0c28_o.jpg


 
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