Chemical fixation has long been the gold standard for preservation of structure. In other words, it is clearly proven to accurately preserve the exact location and size of every synapse. Are some of the lipids getting washed out? Yes. But any micrograph you see on the Alcor website proving good cryopreservation is a micrograph of tissue that has been chemically fixed. It must be in order to view it under a microscope. It is well understood in histology that the fixative does not alter structure.
