Just one quick question for Mike, who writes in the conclusion of his post:
"Cryonicists face the difficult choice of either abandoning cardiopulmonary support during stabilization operations, returning to the use of the previously employed drugs to ensure cardiocerebral arrest and complete skeletal muscle paralysis, or adopting novel pharmacological strategies to achieve these ends."
I am curious to know what you might think about abandoning only the "pulmonary" portion of CPS, for cryonics patients. In other words, how do you feel about simply providing circulatory support (chest compressions) to circulate meds and facilitate cooling, without the administration of oxygen?
I'm sure you are familiar with the works of Dr. Lance Becker, but I will post this brief snippet for anyone who may not have seen it, in previous discussions on this forum:
“What we found when we studied oxygen deprivation in cells astounded us,” explained Becker. “When cells are deprived of oxygen for an hour there is only 4% cell death. After four hours, cell death is only around 16%. Both of these numbers are low. The amazing thing was once we re-introduced oxygen to the cells they died off rapidly to almost 60% cell death. This re-oxygenation injury we termed reperfusion injury. We concluded that the re-introduction of oxygen must be handled carefully for the majority of cells to survive. Our studies will be concentrating on ways to prepare cells deprived of oxygen for the re-introduction of oxygen.”
http://www.uphs.upenn.edu/news/News_Releases/apr07/resuscitation-center.html
Many thanks to Mike for his informative post.