Hawking and the End of Theories
Stephen Hawking is still one of the chief authorities on incredibly weird, complex physics, but even he apparently doubts that there's a final answer to all the universe's questions. He claims that scientists should instead adopt a point of view called "model-dependent realism":
"This radical theory holds that there doesn't exist, even in principle, a single comprehensive theory of the universe. Instead, science offers many incomplete windows onto a common reality, one no more "true" than another. In the authors' hands this position bleeds into an alarming anti-realism: not only does science fail to provide a single description of reality, they say, there is no theory-independent reality at all."
You could claim that the reason that scientists can't find a theory of everything is because our knowledge of the universe is still growing, or you could side with Hawking and say there is no 'theory' to find. Either way, we've come to a point where we've started making theories about the theory of everything. As you can imagine, that causes some problems.