This is a good read, I recall the show...made an impression!
http://www.fighttimes.com/magazine/magazine.asp?article=730
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Discovery Channel series about martial arts, they determined that the knee kick is the single most powerful weapon in the human arsenal. Hooking professional fighters up to all sorts of computer equipment, they discovered that the force of impact of a knee kick is equivalent to being hit by a car.
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As I recall it was about 35 mph impact to chest.
So a knee used in the combination is very effective, most are not using the knee, to its best advantage.
Knee drills are in the article, but you can damage it, (knee) for life also.
Soft spots are best IMHO.
Gary