Is on Madison between 62nd and 63rd. A little farther uptown than most of the watch boutiques. Near there is also Goyard where you can find a new backpack to test
I'm not local to NYC, but know a few spots to suggest
Lange is North a few blocks at 785 Madison. Be sure to say hi to Lindsey there! The AP boutique is great on 57th between Madison and Park. Some people have complained of aloof salespeople, but they have been very friendly when I've stopped in. Wempe, Cellini, Tourneau are all nearby. Rolex (Wempe) Boutique and Patek is in Tiffany and Wempe.
Then there is the Diamond District on 47th street. Ton's of pre-owned and grey market watches to see there.
If you are looking for outdoor equipment/supply type stores there are several in SOHO. (REI, Patagonia, Snow Peak, Burton, G-Shock, etc.) The Leica boutique is also in SOHO if you want to pick up a new SL and a few lenses.
If you want American workwear type stuff (Levi, Red Wing, Lee, Carhartt, etc.) try Dave's New York. 6th Ave between 16th and 17th.
Then of course there's the food........