That depends. 10+ with a lot of deck clearance usually means less resistance to detonation. Typically you want to keep the deck to under .050, tighter if possible. The 302 I have picked up about 20HP just from cutting the deck clearance from .012 to zero to end up at 9.5:1. It runs fine on 91 with a 216 intake duration and a 110 lobe center. My 10.5:1 351C requires 93 octane to keep it off the hairy edge. That's with about 230 intake duration and a 108 lobe center cam. you'll need to keep an eye on the plugs and fiddle with the total ignition advance.
Typically Good to reduct detonation - tight deck, long intake duration, tight intake duration (lower number, more overlap)
Typically Bad for detonation - lots of deck clearance, small intake duration, wide lobe center (builds cylinder pressure)
1967 Falcon 4 door 351C-4V
1970 Mustang 351C-2V
http://raceabilene.com/kelly/hotrod
Owner built, owner abused.