make a nickels worth of difference. In my .22 rimfire days I've witnessed a rib shot squirrel run 20 yards before expiring after being hit with over 100fpe. Also, I've had full pellet penetration on rib shot squirrels at 20 yards when using my old 10fpe HW35 so I personally don't believe the "all energy transfered to the target" hype.
I personally prefer full penetration THROUGH THE VITALS and it doesn't matter to me if full penetration is achieved with 8 fpe or 20.........especially after seeing more than one squirrel take a 100+ fpe hit from a .22 rimfire and keep on trucking for quite a few yards.