This is a topic that comes up about every two months and was just recently revisited. Suggest scrool down the past few pages and you will see a varied set of responses.
I feel that Rugers like to shoot dirty, as some others do, while the other contingent are very diligent about taking the whole shootin' iron apart after just a few hundred rounds.
I have two 22/45s and in the year since I bought them have never field stripped once. Stopped counting the rounds through them but average about 250 per gun per week, so figure about 2500-3200 per gun over last year.
I clean them with Hoppes #9 and run a bore snake a couple times perhaps every 600-750 rounds and get out the obvious stuff. Don't use much oil after, either. I get maybe one or two stovepipes every 600-750 rounds using this method.
The amount of dirt you will collect is also a function of the ammo you use, so shooting real dirty stuff may cause you to need to scrub more often. I find Thunderbolt to be really dirty and avoid it.