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As most of your may already know, I am in the mourning the loss of my uterus phase. But I want to share my lesson with you, so that you can learn from my mistake and make a better decision.
High stim is very effective for good responders, which most of us 40+ are not. I had 4 back to back medium-to-high stim IVFs at the beginning of the year, 2 of them stacked month after month, with the rest a natural cycle in between. I researched the impact myself before going in, there is really no conclusion. My RE at Stanford advocated it citing no proof on negative effect, but when I talked to other REs, the general consensus is at least 8 weeks between high stim if not even longer.
At first I thought it was because the ovaries may be overloaded. Until I talked to my oncologist who treats my precancerous uterine condition which surfaced after the intensive IVF regimen. He told me that the E2 generated prior to retrieval is essentially unopposed estrogen dominance, and such amount of estrogen is above and beyond what our body is designed to deal with normally. Excess estrogen is what causes many cancers of the reproductive system including uterus, ovary, cervix and breast, which is why he had encountered pregnant cancer patient who underwent many rounds of IVF. Of course, everyone's estrogen receptors are a bit different, mine are more sensitive, so a bit more boost of estrogen throughout 4 cycles can bring on precancerous changes. The medical establishment will never tell you that there is a link between IVF protocols and cancer, because IVF has become such a gigantic business that they will have enough "research funds" and lobbyists to "prove" otherwise.
Which is why I am more determined to go the mini-IVF route, one or two eggs at a time, much less estrogen in follicular phase, and the combined cost of 3 cycles which yield me just as many eggs as in one cycle is even lower than one full cycle. Most importantly, it is better for my body.
I believe that if Alexis with all the money her mom can spare for her, chooses not to blast her ovaries every few months but to go for natural or low-stim every month, must have a better medical advice than me, since money is not an issue for her.
Therefore, I would caution those who are poor responders like me to be very careful about high stim, and go for regular checkup and biopsy. Just keep in mind that IVF entails health risk and you must monitor very carefully.
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