That's a tough oneMay 17 2012 at 1:49 PM
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|TenaciousB (Login TenaciousB)|
Response to Tenacious B, I need input on genetic testing approaches
Hi MIR! That's is a tough one. This kind of testing (Array CGH, Micro-array CGH, CCRM CCS, 3-Day, 5-Day)...is all so new, it's hard to know what's safest/best for the embryos. I am not up on the statistics, but I think you should go for whatever scenario your lab recommends. My sense is you don't want to push their skill set or have your embryos be the "guinea pigs."
SIRM-NY's embryologist is currently doing 3-Day biopsies (removing 1 cell from a 6-10 cell embryo). That way, they can send the biopsies out to the Reprogenetics lab to get the results by day 5 (& either do a 5-6 day fresh transfer or vitrify 5-6 day blasts). I believe they do it that way because the embryologist feels very comfortable with Day 3 biopsies. Personally, I want to do whatever you embryologist feels is most within his/her skill set.
Is a Day 2 biopsy called a "polar body" biopsy?
Regarding Day 5 CGH testing, Dr. Sher prefers that method over Day 3 (per his blog ivfauthority.com --- another good place to search for CGH info). However, I think his Vegas embryolgist usually biopsies prior to freeze, then vitrifies (the 5-day results take a couple of weeks to come back).
With regard to double-freezing, I think Sher would recommend freezing earlier (day 2 or 3), then growing to blast before biopsying, then vitrifying again. They don't like thaw and freeze them again on the same day.
Dr. Sher is pretty active in answering questions through his Vegas discussion board on haveababy.com. Maybe you could ask him for advice there. Dr. T doesn't check the NYC discussion board as frequently, but it couldn't hurt to ask him, too.
Wish I could be more helpful. Please keep us posted about your research and what you decide!!