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I did back to back 450/150 and 300/150, and I had the worst cycle of my life, pretty much everything died by day 3, which never happened to me before. I rested two months and then was able to get 2 day 3 8-cells.
I consulted with a few doctors regarding back to back cycles, and most of them contend that this hurts egg quality - your ovaries are overworked.