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40-something natural pregnancies do happen. I'm fortunate enough to be pregnant with a second child, and I'll be 44 next week. We're expecting a healthy girl in about 6 weeks.
I live in Northern VA, and around here it seems fairly common to have kids a bit later in life. I've got several mom friends who had their first right around 40 and still hoping for more. My parents had me and my sister in their late 30's, and I personally think later parenting comes with a certain amount of stability that is good for kids.
I do think having kids later means you have to be diligent about your health as much as you can (and frankly I'll probably be coloring my hair until the youngest is out of college!), but I don't really see an issue having kids at this age. My grandmother had two of her kids after 40, the youngest being my dad at 45, so that might color my perspective. I think if it weren't for birth control, we'd find alot more women having kids in their 40's.