You will find lots of support and info here. sounds like you have info on important factors (proven and background). by background I assume you mean donor and family medical history. Ask any questions. My first DE cycle I did with my home clinic and an agency donor. Two potential negatives of this route are the cost and potential cycle delays. I had a six month delay from payment to agency and singing contract. if you use an agency I would suggest getting references from prior clients. Our first cycle was not successful and we have moved on to out of town cycling at Shady Grove in MD for guarantee program. selected donor one week ago and so far process has been much eSier than first DE cycle.