For almost 8 years my husband and I have tried and tried to have a child, and despite my high fsh, I always got a couple of good quality embies during my numerous ivfs with oe. I have had low chemicals with every ivf with my own eggs and a miscarriage after heartbeat.
I tried to do the repro immunology thing myself -- had my OBGYN run the tests, I thought -- she did an antiphospholipid panel and saw a minor clotting disorder, but did not think much of it. I did a donor cycle with a friend donating, and despite good embies, no pregnancy on the fresh of frozen. I was skeptical, and thought I could figure it out myself.
This past year, before we tried an agency donor and gave it one last shot, I changed to an RE who is also an RI, and went ahead and let him run all the bloodwork and panels - and my nurse just called tonight to tell me I had a positive thrombophilia panel, with MTHR and numerous factors. I will get more information about it.
I am sort of reeling that I looked into all of this but only in a half-a..., skeptical way, and perhaps have prevented my success all this time. I just don't believe someone has as many failures as I have without something to detect. (Husband has had a serious workup and he is better than average).
I am now thrilled that we can be hopeful for our upcoming cycle, but also sad looking back on everything we have been through, the toll it has taken on us financially, emotionally, and even though I feel like I have moved on, this makes me mourn the genetic connection again...
It's definitely worth looking into an RI if you have had so many failure with good embies.