I gave every single shot to myself and it wasnt difficult. I am almost 9 weeks pregnant so my RE has been lowering the dose. Set up the shots, than turn on your heating pad and lie on heating pad for 10 minutes. I laid on my bed and had the nurse in the beginning draw a circle of where the shot should go. Clean it with alchol pad, pull back to see no blood and inject. The needle only hurts at the very tip, which is only a second. I put alot of pillows behind my back, lie on my side with the side I was injecting up. It is not difficult. Try to relax the side you are injecting by taking all weight off of it. You will get more relaxed with each injection. Goodluck!!