After transfering perfect 5 day blasts in three fresh DE cycles and the fet from cycle #3 - we had not even had a chemical, and no explanations, no immune issues were showing up on tests and we had transferred 2 blasts the first cycle, then three on each of the following and always had linings of 9+. I'd also had bio children when younger, so knew my body COULD do it.
For our Fourth Fresh DE cycle, we changed quite a bit - did b/c instead of Lupron, since Lupron over suppresses me. I started prednisone at the same time I started estrogen, taking 5mg three times a day. We also used DS, even though DH's had looked great every time and the DNA Frag came back fine; we were just fed up with doing the same things time and again. I did PIO injections every other day, with crinone every night instead of progesterone pills as my body doesnt seem to absorb the pills. The Dr suggested "anti rejection' injections the day before and day of transfer (just more steroids). We again transferred three grade 1 blasts, it was a six day transfer due to complications on day 5. BFP with a singleton.
We then did an FET using the last three blasts from donor cycle #4, and did everything the same- b/c, started prednisone early, anti rejection injections. All three blasts survived the thaw, we transferred all three, and are again pg with a singleton.
In all it took us 6 transfers and 17 grade 1, five day blasts from four fresh cycles and two FETs to get our little guy and the one we are pg with now. We'll never know what finally brought us success - it might have been one of the things we changed, a combination of all, or the heavens finally aligning properly.
I still think its just a crap shoot. Some people get lucky, others have to keep playing and paying the game. The doctors themselves have no idea why some cycles work and some dont. Its just amazing when you think about it: all the science, all the technology, and it can still only take us to transfer, after that, its still up to the wind, the univserse, whatever god(ess) you believe in, crossing fingers, saying prayers and wishing on the stars.
Good luck!
Kay
" Some people built castles in the air. She constructed hers from mashed potatoes, which kept down demolition costs." Sarah Sloane, Borrowing Priviledges