lining thickness. Sounds like your levels are high because of the HRT. That you lining is thin with this estrogen level may mean that you will need estrogen supplementation at either a higher level and/or a different delivery method (injectable,vaginal, etc.) My E2 numbers were over 2000 at one point, when taking it to thicken my lining. I have seen over women with numbers between 100 and 300 and have thick lining. It is a very individual thing. The US gives the most accurate picture.