Hi Seymo: I asked my SG RE about Crinone. I wanted to use it to supplement the 1 cc of PIO that is in the protocol because at previous clinic I was on 2 cc plus Crinone once a day. RE would not let me use Crinone (i had two plus boxes left over from previous cycle at old clinic). He did prescribe Endometrin which is a vaginal suppository. I currently taking the injectable PIO and one endometrin at night. If I get a BFP plan is to take me off the injectible PIO and up the endometrin to three times a day once there is a heartbeat. I'm not sure how Endometrin compares on terms of effectiveness to Crinone however it is definitely less messy (Crinone is a gel/cream like substance and very leaky even when I stayed in bed for half hour after insertong. Endometrin is chalk like tablet. There is a little leaking after it melts but nothi g like the Crinone). I'm not sure if the no Crinone is a SG thing or just my RE issue. I asked abput it once to him and with two different nurses and was told no even when I told them I had an unused supply.