Well, I would start with tests for her and DH to eliminate other
|February 16 2012, 4:04 AM |
reasons for failure other than chromsomally abnormal embryos (which is of course possible with DE).
Thyroid for her - TSH (between 1 and 2 v. important), T3, T4 and antithyroid antibodies
Sperm testing for DH including a karyotype to detect any genetic issues, dna fragmentation testing etc.
Uterine - She needs a hysteroscopy to determine whether any issues with uterus
Clotting - she needs testing for basic clotting: MTHFR, Factor V Leiden, APS, anticardiolipin, lupus anticoagulant, prothrombin gene mutation, PA1, etc.
Infection - she and DH need testing for mycoplasma, ureaplasma, chlamydia, group B strep
What was her lining like at transfer? Triple stripe?
Did she have adequate progesterone levels at beta test??
Donor is not proven so this could be an issue?
What are clinic's embryologists like? How experienced and what are stats for fresh and frozen?
Are they experienced and successful with blast transfer?
On average, how many cycles does it take 1 woman at their clinic to achieve a live birth with DE fresh and frozen??
What reasons do they give for failure and ask them to run above tests.
What testing has donor had? What was AFC, what was fertilization like? What did embryos look like? How did they stim her?
Two chemicals may indicate embryo issues, egg or sperm issues individually, or implantation issues due to problems with your friend (see above tests).
She would be advised not to cycle until she has had some testing IMHO.
Best of luck to her,