After NUMEROUS failures with proven donors, I did a test called EFT which was developed by a doctor at Yale. I've posted about this before.
This web site has lots of good background information about the test:
Based on cellular abnormalities that were discovered from my biopsy, it was recommended to use progesterone that is delivered vaginally only, no PIO shots (a lovely bonus). Below is the protocol:
I started with 25 mg of progesterone vaginally the night before the donor's retreval.
Day of retrieval was 25 mg in the morning and at night.
Days 1 through 3 of fertilization was 25 mg twice per day.
Day 4 of fertilization was 50 mg twice per day.
Transfer day was 100 mg twice per day -- same dosage for the next 3 days.
Then 5 days post my day 5 transfer (or 10 DPO) the dose was increased to 200 mg twice per day and continued through my beta and also after my positive result.
The lower doses were progesterone in oil gel caps that needed to be refrigerated. The 100 and 200 mg doses were prometrium suppositories.
Two days after transfer my clinic always tests estrogen and progesterone levels. My P levels were a tiny bit low - they explained that vaginal delivery sometimes doesn't show up as strong in bloodwork as the shots do. However, just to be extra cautious, they decided it couldn't hurt to add Crinone to my daily route. After my 10 week ultrasound I stopped taking all progesterone.
Best of luck to you!