Not a lot of safety training needed, Joe. First and foremost, protect the tank valve from any possibility of getting knocked off. If it's standing, chain it to something solid so it can't fall over. Laying down is fine, but again, make sure the valve is protected from possible hits.
The Disco uses a standard Foster quick fill, also known as a paint ball fitting. These are readily available lots of places, were originally sold as hydraulic fittings, and most are rated at least 3000 psi, on up to 5000 or more. And remember, even if your tank pressure is 4500 or 6000 psi, the fitting attached to the gun will only "see" 3000 psi or less, 2000 in the case of the Disco. Joe is a good source, especially for a complete, ready to go rig, but if you're willing to do some leg work, you can save some money (sorry, Joe). This is the setup I put together for a 4500 psi tank:
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I've probably got around $100 in this, most of it I bought at my local NAPA auto parts store.
I highly recommend N2 over HPA, I think my guns shoot better, although I don't have any hard data to support that, I've been using N2 since I got my first PCP. On the rare occasions I've shot them on air, they didn't seem to hit as hard or be as consistent. Hope this helps, and if you'd like more info, feel free to email me direct. Later.
Dave