Lora,
The first puppy we lost (last month) became ill and lifeless like overnight. Docs thought it was toxin, I felt horrible like I had missed something and he'd gotten into it, as careful as I was. Turned out, the lab tests came back okay, but pup had congestive heart failure. Put it down the next day...went into pulmonary edema.
THIS puppy acts fine, most of the time. Gets a little irritable, out of control irritable, can't be made submissive like most dogs, or is asleep. Clumsy, like me, altered gait, big head. When she is lovey dovey, she's a little angel. 3 vets say it's hydro.
Maybe God is telling me not to add any more puppies (puggles) to the family for awhile.