Slow pokes chars:
There might be a limit on AP, even with a very low AGI. But all the other skills that depends on it will take a beating obviously. All in all, I'm guessing low AGIs will be very tough to play during the early stages. I'm going to guess that the char will become very much like a turtle in the late game. Pile on the armor, damage reduction via perk and operations, and high HP.
Dimwits and Speek-no-good:
If you go to the pure combat route, not as hard as it sounds. Though you will cherish every single skill point you can get.
Non Gigolo and Mojo-less-Lasses.
Heh, I guess everybody needs some lovin, even in the Wastelands. Thankfully they have no karmic title of Brahmin... uh.. never mind.
"Shoot enemy with
Burst weapon at close range, then switch to melee and
knockback to longer range."
Depends on the skill rating and stats. I tried this with a char with approximately 40 skill in Small guns. His to-hit rating was in the -100's. This was standing about 2 squares next to the target.
That is probably a stretch in real world terms, since it would be hard to miss someone with an automatic weapon. At point blank range.
But the system works beatifully in the game world. Don't have the skill to wield that G-11? Then you probably would hit everything BUT the target.
As for the rope in FO2. I only heard about this, haven't tried it myself. But supposedly there is a well you can go down to, using the rope. Nothing earth shattering though. Fans of "Goonies" might recognize it though. Heard it's located in the town where you meet your spouse.